ERP44

Endoplasmic reticulum resident protein 44 (ERp44) also known as thioredoxin domain-containing protein 4 (TXNDC4) is a protein that in humans is encoded by the ERP44 gene.[5][6][7]

ERP44
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2R2J
Identifiers
Aliases	ERP44, PDIA10, TXNDC4, endoplasmic reticulum protein 44
External IDs	OMIM: 609170 MGI: 1923549 HomoloGene: 12638 GeneCards: ERP44
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 99,979,185 bp[1] End 100,099,000 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 48,193,323 bp[2] End 48,279,558 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • protein disulfide isomerase activity Cellular component • cell surface • endoplasmic reticulum lumen • extracellular exosome • endoplasmic reticulum membrane • endoplasmic reticulum • endoplasmic reticulum-Golgi intermediate compartment • extracellular region • specific granule lumen Biological process • response to unfolded protein • glycoprotein metabolic process • protein folding • response to endoplasmic reticulum stress • cell redox homeostasis • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23071	76299
Ensembl	ENSG00000023318	ENSMUSG00000028343
UniProt	Q9BS26	Q9D1Q6
RefSeq (mRNA)	NM_015051	NM_029572 NM_001355184
RefSeq (protein)	NP_055866	NP_083848 NP_001342113
Location (UCSC)	Chr 9: 99.98 – 100.1 Mb	Chr 4: 48.19 – 48.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TXNDC4 has been shown to interact with ERO1L.[5][7]

References

1. GRCh38: Ensembl release 89: ENSG00000023318 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028343 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R (Feb 2002). "ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family". The EMBO Journal. 21 (4): 835–44. doi:10.1093/emboj/21.4.835. PMC 125352. PMID 11847130.
6. "Entrez Gene: TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum)".
7. Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.

Further reading

• Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C, Sitia R (Oct 2007). "Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis". The EMBO Journal. 26 (19): 4177–88. doi:10.1038/sj.emboj.7601844. PMC 2230840. PMID 17805346.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, Sitia R (2006). "Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44". Antioxidants & Redox Signaling. 8 (3–4): 274–82. doi:10.1089/ars.2006.8.274. PMID 16677073.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, Mikoshiba K (Jan 2005). "Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44". Cell. 120 (1): 85–98. doi:10.1016/j.cell.2004.11.048. PMID 15652484. S2CID 12398022.
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (Nov 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R (Oct 2003). "Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44". The EMBO Journal. 22 (19): 5015–22. doi:10.1093/emboj/cdg491. PMC 204474. PMID 14517240.
• O'Neill EE, Brock CJ, von Kriegsheim AF, Pearce AC, Dwek RA, Watson SP, Hebestreit HF (Mar 2002). "Towards complete analysis of the platelet proteome". Proteomics. 2 (3): 288–305. doi:10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0. PMID 11921445.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.