Short-chain acyl-CoA dehydrogenase

Short-chain acyl-CoA dehydrogenase (EC 1.3.8.1, butyryl-CoA dehydrogenase, butanoyl-CoA dehydrogenase, butyryl dehydrogenase, unsaturated acyl-CoA reductase, ethylene reductase, enoyl-coenzyme A reductase, unsaturated acyl coenzyme A reductase, butyryl coenzyme A dehydrogenase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, 3-hydroxyacyl CoA reductase, butanoyl-CoA:(acceptor) 2,3-oxidoreductase, ACADS (gene).) is an enzyme with systematic name short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

a short-chain acyl-CoA + electron-transfer flavoprotein a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
Short-chain acyl-CoA dehydrogenase
Short-chain acyl-CoA dehydrogenase tetramer, Human
Identifiers
EC number1.3.8.1
CAS number9027-88-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme contains FAD as prosthetic group.

See also

References
  1. Mahler HR (January 1954). "Studies on the fatty acid oxidizing system of animal tissues. IV. The prosthetic group of butyryl coenzyme A dehydrogenase". The Journal of Biological Chemistry. 206 (1): 13–26. PMID 13130522.
  2. Green DE, Mii S, Mahler HR, Bock RM (January 1954). "Studies on the fatty acid oxidizing system of animal tissues. III. Butyryl coenzyme A dehydrogenase". The Journal of Biological Chemistry. 206 (1): 1–12. PMID 13130521.
  3. Beinert H (1963). "Acyl coenzyme A dehydrogenase". In Boyer PD, Lardy H, Myrbäck K (eds.). The Enzymes. 7 (2nd ed.). New York: Academic Press. pp. 447–466.
  4. Shaw L, Engel PC (March 1984). "The purification and properties of ox liver short-chain acyl-CoA dehydrogenase". The Biochemical Journal. 218 (2): 511–20. doi:10.1042/bj2180511. PMC 1153367. PMID 6712627.
  5. Thorpe C, Kim JJ (June 1995). "Structure and mechanism of action of the acyl-CoA dehydrogenases". FASEB Journal. 9 (9): 718–25. doi:10.1096/fasebj.9.9.7601336. PMID 7601336. S2CID 42549744.
  6. Ikeda Y, Okamura-Ikeda K, Tanaka K (January 1985). "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme". The Journal of Biological Chemistry. 260 (2): 1311–25. PMID 3968063.
  7. McMahon B, Gallagher ME, Mayhew SG (September 2005). "The protein coded by the PP2216 gene of Pseudomonas putida KT2440 is an acyl-CoA dehydrogenase that oxidises only short-chain aliphatic substrates". FEMS Microbiology Letters. 250 (1): 121–7. doi:10.1016/j.femsle.2005.06.049. PMID 16024185.
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