STX1B

Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.[5]

STX1B
Identifiers
Aliases	STX1B, STX1B1, STX1B2, GEFSP9, syntaxin 1B
External IDs	OMIM: 601485 MGI: 1930705 HomoloGene: 69375 GeneCards: STX1B
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,989,256 bp[1] End 31,010,638 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,803,900 bp[2] End 127,824,549 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SNAP receptor activity • protein kinase binding • receptor binding • SNARE binding • protein domain specific binding Cellular component • integral component of membrane • cytosol • membrane • synaptic vesicle • cell membrane • spindle • microtubule organizing center • SNARE complex • cytoskeleton • nuclear lamina • cell nucleus • nucleoplasm • centrosome • cytoplasm • presynaptic membrane • presynapse • presynaptic active zone membrane • axon • neuromuscular junction • endomembrane system Biological process • synaptic vesicle docking • spontaneous neurotransmitter secretion • positive regulation of neurotransmitter secretion • regulation of exocytosis • vesicle docking • positive regulation of excitatory postsynaptic potential • regulation of gene expression • protein transport • intracellular protein transport • neurotransmitter transport • vesicle-mediated transport • regulation of synaptic vesicle priming • negative regulation of neuron projection development • regulation of synaptic activity • vesicle docking involved in exocytosis • calcium ion-regulated exocytosis of neurotransmitter • protein localization to membrane • negative regulation of synaptic vesicle recycling • positive regulation of spontaneous neurotransmitter secretion • negative regulation of macropinocytosis • synaptic vesicle fusion to presynaptic active zone membrane • exocytic insertion of neurotransmitter receptor to postsynaptic membrane • synaptic vesicle exocytosis • exocytosis • vesicle fusion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	112755	56216
Ensembl	ENSG00000099365	ENSMUSG00000030806
UniProt	P61266	P61264
RefSeq (mRNA)	NM_052874	NM_024414
RefSeq (protein)	NP_443106	NP_077725
Location (UCSC)	Chr 16: 30.99 – 31.01 Mb	Chr 7: 127.8 – 127.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

STX1B has been shown to interact with UNC13B.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000099365 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030806 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: STX1B2 syntaxin 1B2".
6. Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

Further reading

• Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
• Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.
• Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamaguchi S, Ni J, Itagaki E, Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". Journal of Cell Science. 114 (Pt 1): 219–227. PMID 11112705.
• Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
• Smirnova T, Miniou P, Viegas-Pequignot E, Mallet J (September 1996). "Assignment of the human syntaxin 1B gene (STX) to chromosome 16p11.2 by fluorescence in situ hybridization". Genomics. 36 (3): 551–3. doi:10.1006/geno.1996.0506. PMID 8884284.
• Smirnova T, Stinnakre J, Mallet J (October 1993). "Characterization of a presynaptic glutamate receptor". Science. 262 (5132): 430–3. doi:10.1126/science.8105537. PMID 8105537.