CLTB

Clathrin, light chain B is a protein in humans that is encoded by the CLTB gene.[5]

CLTB
Identifiers
Aliases	CLTB, LCB, clathrin light chain B
External IDs	OMIM: 118970 MGI: 1921575 HomoloGene: 37532 GeneCards: CLTB
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,392,455 bp[1] End 176,416,569 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 54,592,401 bp[2] End 54,611,344 bp[2]
Gene ontology Molecular function • clathrin heavy chain binding • peptide binding • GO:0001948 protein binding • structural molecule activity Cellular component • ciliary membrane • clathrin-coated pit • clathrin coat of trans-Golgi network vesicle • membrane • cytoplasmic vesicle membrane • cytoplasmic vesicle • clathrin coat of coated pit • intracellular membrane-bounded organelle • trans-Golgi network • clathrin vesicle coat • clathrin coat • cell membrane • cytosol • synaptic vesicle membrane • clathrin-coated endocytic vesicle • presynaptic endocytic zone membrane • postsynaptic endocytic zone cytoplasmic component Biological process • clathrin-dependent endocytosis • vesicle-mediated transport • intracellular protein transport • membrane organization • clathrin coat assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1212	74325
Ensembl	ENSG00000175416	ENSMUSG00000047547
UniProt	P09497	Q6IRU5
RefSeq (mRNA)	NM_001834 NM_007097 NM_001364126 NM_001364127	NM_028870 NM_001347512
RefSeq (protein)	NP_001825 NP_009028 NP_001351055 NP_001351056 NP_001825.1	NP_001334441 NP_083146
Location (UCSC)	Chr 5: 176.39 – 176.42 Mb	Chr 13: 54.59 – 54.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and coated vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000175416 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047547 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Clathrin, light chain B". Retrieved 2013-06-05.

Further reading