Syntaxin binding protein 3

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.[5][6]

STXBP3
Identifiers
Aliases	STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3
External IDs	OMIM: 608339 MGI: 107362 HomoloGene: 5260 GeneCards: STXBP3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 108,746,674 bp[1] End 108,809,523 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F3 Start 108,793,176 bp[2] End 108,840,526 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • syntaxin-1 binding • GO:0001948 protein binding • syntaxin binding Cellular component • cytoplasm • platelet alpha granule • cytosol • membrane • tertiary granule • cell membrane • basolateral plasma membrane • specific granule • apical plasma membrane • extracellular exosome • phagocytic vesicle • presynapse Biological process • protein to membrane docking • protein heterooligomerization • neutrophil degranulation • insulin secretion • vesicle docking involved in exocytosis • response to insulin • brain development • negative regulation of calcium ion-dependent exocytosis • protein transport • platelet aggregation • vesicle-mediated transport • exocytosis • transport • cellular glucose homeostasis • negative regulation of glucose import • cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6814	20912
Ensembl	ENSG00000116266	ENSMUSG00000027882
UniProt	O00186	Q60770
RefSeq (mRNA)	NM_007269	NM_011504
RefSeq (protein)	NP_009200	NP_035634
Location (UCSC)	Chr 1: 108.75 – 108.81 Mb	Chr 3: 108.79 – 108.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Syntaxin binding protein 3 has been shown to interact with STX2[7] and STX4.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000116266 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027882 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. doi:10.1182/blood.V93.8.2617. PMID 10194441.
6. "Entrez Gene: STXBP3 syntaxin binding protein 3".
7. Schraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
8. Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (November 1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants". The Journal of Neuroscience. 16 (21): 6695–702. doi:10.1523/JNEUROSCI.16-21-06695.1996. PMC 6579271. PMID 8824310.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (August 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Fu J, Naren AP, Gao X, Ahmmed GU, Malik AB (February 2005). "Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression". The Journal of Biological Chemistry. 280 (5): 3178–84. doi:10.1074/jbc.M410044200. PMID 15576373.
• Hodgkinson CP, Mander A, Sale GJ (June 2005). "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking". The Biochemical Journal. 388 (Pt 3): 785–93. doi:10.1042/BJ20041845. PMC 1183457. PMID 15707389.