PTPRH

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.[5][6]

PTPRH
Identifiers
Aliases	PTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H, protein tyrosine phosphatase receptor type H
External IDs	OMIM: 602510 MGI: 3026877 HomoloGene: 37693 GeneCards: PTPRH
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,181,247 bp[1] End 55,209,506 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,548,612 bp[2] End 4,604,041 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • GO:0001948 protein binding • phosphoprotein phosphatase activity • hydrolase activity Cellular component • cytoplasm • integral component of membrane • integral component of plasma membrane • membrane • cell membrane • microvilli • apical plasma membrane • microvillus membrane • cell projection Biological process • protein dephosphorylation • dephosphorylation • apoptotic process • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5794	545902
Ensembl	ENSG00000080031	ENSMUSG00000035429
UniProt	Q9HD43	E9Q0N2
RefSeq (mRNA)	NM_001161440 NM_002842	NM_207270
RefSeq (protein)	NP_001154912 NP_002833	NP_997153
Location (UCSC)	Chr 19: 55.18 – 55.21 Mb	Chr 7: 4.55 – 4.6 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080031 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035429 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem. 269 (3): 2075–81. PMID 8294459.
6. "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H".

Further reading

• Noguchi T, Tsuda M, Takeda H, et al. (2001). "Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas". J. Biol. Chem. 276 (18): 15216–24. doi:10.1074/jbc.M007208200. PMID 11278335.
• Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome". Cytogenet. Cell Genet. 92 (3–4): 213–6. doi:10.1159/000056905. PMID 11435690. S2CID 20187527.
• Takada T, Noguchi T, Inagaki K, et al. (2002). "Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1". J. Biol. Chem. 277 (37): 34359–66. doi:10.1074/jbc.M206541200. PMID 12101188.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagano H, Noguchi T, Inagaki K, et al. (2003). "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma". Oncogene. 22 (30): 4656–63. doi:10.1038/sj.onc.1206588. PMID 12879010.
• Pasquali C, Curchod ML, Wälchli S, et al. (2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor". Mol. Endocrinol. 17 (11): 2228–39. doi:10.1210/me.2003-0011. PMID 12907755.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.