CDC25C

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.[5]

CDC25C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OJX, 3BZI, 3OP3
Identifiers
Aliases	CDC25C, CDC25, PPP1R60, cell division cycle 25C
External IDs	OMIM: 157680 MGI: 88350 HomoloGene: 1356 GeneCards: CDC25C
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 138,285,265 bp[1] End 138,338,355 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 18.71 cM Start 34,732,993 bp[2] End 34,751,533 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • WW domain binding • protein tyrosine phosphatase activity • hydrolase activity • protein kinase binding • phosphoprotein phosphatase activity Cellular component • cytoplasm • cytosol • intracellular • nucleoplasm • perinuclear region of cytoplasm • cell nucleus • nuclear speck Biological process • regulation of cyclin-dependent protein serine/threonine kinase activity • protein dephosphorylation • regulation of cell cycle • cell division • DNA replication • G2/M transition of mitotic cell cycle • spermatogenesis • cell cycle • cellular proliferation • GO:0022415 viral process • regulation of mitotic nuclear division • peptidyl-tyrosine dephosphorylation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cell cycle G2/M phase transition • positive regulation of G2/M transition of mitotic cell cycle • positive regulation of mitotic cell cycle • positive regulation of G2/MI transition of meiotic cell cycle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	995	12532
Ensembl	ENSG00000158402	ENSMUSG00000044201
UniProt	P30307	P48967
RefSeq (mRNA)	NM_001287582 NM_001287583 NM_001790 NM_022809 NM_001318098 NM_001364026 NM_001364027 NM_001364028	NM_009860
RefSeq (protein)	NP_001274511 NP_001274512 NP_001305027 NP_001781 NP_073720 NP_001350955 NP_001350956 NP_001350957	NP_033990
Location (UCSC)	Chr 5: 138.29 – 138.34 Mb	Chr 18: 34.73 – 34.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.[6]

Interactions

CDC25C has been shown to interact with MAPK14,[7] CHEK1,[8] PCNA,[9] PIN1,[10][11][12] PLK3[13] and NEDD4.[12]

See also

• Cdc25

References

1. GRCh38: Ensembl release 89: ENSG00000158402 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044201 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science. 250 (4987): 1573–6. Bibcode:1990Sci...250.1573G. doi:10.1126/science.1703321. PMID 1703321. S2CID 25037148.
6. "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)".
7. Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. England. 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986. S2CID 4410763.
8. Sanchez, Y; Wong C; Thoma R S; Richman R; Wu Z; Piwnica-Worms H; Elledge S J (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. UNITED STATES. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511.
9. Kawabe, Takumi; Suganuma Masashi; Ando Tomoaki; Kimura Mayumi; Hori Haruna; Okamoto Takashi (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene. England. 21 (11): 1717–26. doi:10.1038/sj.onc.1205229. ISSN 0950-9232. PMID 11896603.
10. Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.
11. Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
12. Lu, P J; Zhou X Z; Shen M; Lu K P (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. UNITED STATES. 283 (5406): 1325–8. Bibcode:1999Sci...283.1325L. doi:10.1126/science.283.5406.1325. ISSN 0036-8075. PMID 10037602.
13. Ouyang, B; Li W; Pan H; Meadows J; Hoffmann I; Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. ENGLAND. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. ISSN 0950-9232. PMID 10557092.

Further reading

• Draetta G, Eckstein J (1997). "Cdc25 protein phosphatases in cell proliferation". Biochim. Biophys. Acta. 1332 (2): M53–63. doi:10.1016/S0304-419X(96)00049-2. PMID 9141461.
• Nilsson I, Hoffmann I (2000). "Cell cycle regulation by the Cdc25 phosphatase family". Progress in Cell Cycle Research. 4: 107–14. doi:10.1007/978-1-4615-4253-7_10. ISBN 978-1-4613-6909-7. PMID 10740819.
• Amini S, Khalili K, Sawaya BE (2004). "Effect of HIV-1 Vpr on cell cycle regulators". DNA Cell Biol. 23 (4): 249–60. doi:10.1089/104454904773819833. PMID 15142382.
• Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024 (1): 153–67. Bibcode:2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID 15265780. S2CID 23655886.
• Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis". Curr. HIV Res. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722.
• Sartor H, Ehlert F, Grzeschik KH, et al. (1992). "Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively". Genomics. 13 (3): 911–2. doi:10.1016/0888-7543(92)90190-4. PMID 1386342.
• Strausfeld U, Labbé JC, Fesquet D, et al. (1991). "Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein". Nature. 351 (6323): 242–5. Bibcode:1991Natur.351..242S. doi:10.1038/351242a0. PMID 1828290. S2CID 4372756.
• Galaktionov K, Beach D (1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978. S2CID 9659637.
• Sadhu K, Reed SI, Richardson H, Russell P (1990). "Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5139–43. Bibcode:1990PNAS...87.5139S. doi:10.1073/pnas.87.13.5139. PMC 54277. PMID 2195549.
• Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. 69 (11): 6859–64. doi:10.1128/JVI.69.11.6859-6864.1995. PMC 189600. PMID 7474100.
• Zwicker J, Gross C, Lucibello FC, et al. (1995). "Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1". Nucleic Acids Res. 23 (19): 3822–30. doi:10.1093/nar/23.19.3822. PMC 307297. PMID 7479023.
• Di Marzio P, Choe S, Ebright M, et al. (1996). "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. doi:10.1128/JVI.69.12.7909-7916.1995. PMC 189735. PMID 7494303.
• Strausfeld U, Fernandez A, Capony JP, et al. (1994). "Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis". J. Biol. Chem. 269 (8): 5989–6000. PMID 8119945.
• Zheng XF, Ruderman JV (1993). "Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25". Cell. 75 (1): 155–64. doi:10.1016/S0092-8674(05)80092-3. PMID 8402895. S2CID 45351149.
• Taviaux SA, Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization". Genomics. 15 (1): 194–6. doi:10.1006/geno.1993.1032. PMID 8432534.
• Honda R, Ohba Y, Nagata A, et al. (1993). "Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase". FEBS Lett. 318 (3): 331–4. doi:10.1016/0014-5793(93)80540-B. PMID 8440392. S2CID 30754963.
• Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
• Sanchez Y, Wong C, Thoma RS, et al. (1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. PMID 9278511.

External links

• Human CDC25C genome location and CDC25C gene details page in the UCSC Genome Browser.