CDC14B

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.[5][6]

CDC14B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OHC, 1OHD, 1OHE
Identifiers
Aliases	CDC14B, CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B
External IDs	OMIM: 603505 MGI: 2441808 HomoloGene: 104197 GeneCards: CDC14B
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.32-q22.33 Start 96,490,241 bp[1] End 96,619,843 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B3 Start 64,189,268 bp[2] End 64,275,290 bp[2]
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • phosphatase activity • GO:0001948 protein binding • protein serine/threonine phosphatase activity Cellular component • cell nucleus • nucleolus • cytoplasm • nucleoplasm • spindle pole • centrosome • mitotic spindle Biological process • DNA repair • cellular response to DNA damage stimulus • dephosphorylation • protein dephosphorylation • peptidyl-tyrosine dephosphorylation • GO:0090623, GO:1903835, GO:0007092, GO:0051488 positive regulation of ubiquitin protein ligase activity • regulation of exit from mitosis • mitotic spindle midzone assembly • cilium morphogenesis • mitotic cell cycle arrest • signal transduction involved in G2 DNA damage checkpoint • microtubule cytoskeleton organization • GO:0007067 mitotic cell cycle • positive regulation of cytokinesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8555	218294
Ensembl	ENSG00000081377	ENSMUSG00000033102
UniProt	O60729	Q6PFY9
RefSeq (mRNA)	NM_001077181 NM_003671 NM_033331 NM_033332 NM_001351567 NM_001351568 NM_001351569 NM_001351570	NM_001122989 NM_172587
RefSeq (protein)	NP_001070649 NP_003662 NP_201588 NP_001338496 NP_001338497 NP_001338498 NP_001338499	NP_001116461 NP_766175
Location (UCSC)	Chr 9: 96.49 – 96.62 Mb	Chr 13: 64.19 – 64.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.[6]

Interactions

CDC14B has been shown to interact with p53.[7] However, this interaction has not been reported in other studies.

References

1. GRCh38: Ensembl release 89: ENSG00000081377 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033102 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem. 272 (47): 29403–29406. doi:10.1074/jbc.272.47.29403. PMID 9367992.
6. "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)".
7. Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4): 2410–2414. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693.

External links

• Human CDC14B genome location and CDC14B gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Li L, Ljungman M, Dixon JE (2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4): 2410–2414. doi:10.1074/jbc.275.4.2410. PMID 10644693.
• Mailand N, Lukas C, Kaiser BK, et al. (2002). "Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation". Nat. Cell Biol. 4 (4): 318–322. doi:10.1038/ncb777. PMID 11901424. S2CID 28955777.
• Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK (2003). "Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase". Mol. Biol. Cell. 13 (7): 2289–2300. doi:10.1091/mbc.01-11-0535. PMC 117313. PMID 12134069.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dryden SC, Nahhas FA, Nowak JE, et al. (2003). "Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle". Mol. Cell. Biol. 23 (9): 3173–3185. doi:10.1128/MCB.23.9.3173-3185.2003. PMC 153197. PMID 12697818.
• Gray CH, Good VM, Tonks NK, Barford D (2003). "The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase". EMBO J. 22 (14): 3524–3535. doi:10.1093/emboj/cdg348. PMC 165618. PMID 12853468.
• Nalepa G, Harper JW (2005). "Visualization of a highly organized intranuclear network of filaments in living mammalian cells". Cell Motil. Cytoskeleton. 59 (2): 94–108. doi:10.1002/cm.20023. PMID 15362113.
• Cho HP, Liu Y, Gomez M, et al. (2005). "The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules". Mol. Cell. Biol. 25 (11): 4541–4551. doi:10.1128/MCB.25.11.4541-4551.2005. PMC 1140622. PMID 15899858.
• Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP (2005). "Functional homology among human and fission yeast Cdc14 phosphatases". J. Biol. Chem. 280 (32): 29144–29150. doi:10.1074/jbc.M413328200. PMID 15911625.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.