NPR1

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

NPR1
Identifiers
Aliases	NPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDs	OMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,678,688 bp[1] End 153,693,992 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.23 cM Start 90,450,591 bp[2] End 90,465,866 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase activity • nucleotide binding • G-protein coupled peptide receptor activity • hormone binding • guanylate cyclase activity • GTP binding • lyase activity • natriuretic peptide receptor activity • phosphorus-oxygen lyase activity • ATP binding • peptide hormone binding • adenylate cyclase activity • protein kinase binding • peptide receptor activity Cellular component • integral component of membrane • membrane • cell membrane • receptor complex • guanylate cyclase complex, soluble • intracellular Biological process • negative regulation of smooth muscle cell proliferation • regulation of cardiac conduction • GO:0007243 intracellular signal transduction • positive regulation of renal sodium excretion • positive regulation of urine volume • body fluid secretion • cyclic nucleotide biosynthetic process • receptor guanylyl cyclase signaling pathway • regulation of blood pressure • cGMP biosynthetic process • protein phosphorylation • cell surface receptor signaling pathway • regulation of vascular permeability • dopamine metabolic process • negative regulation of cell growth • negative regulation of angiogenesis • G-protein coupled receptor signaling pathway • regulation of blood vessel diameter • positive regulation of cGMP-mediated signaling • cGMP-mediated signaling • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4881	18160
Ensembl	ENSG00000169418	ENSMUSG00000027931
UniProt	P16066	P18293
RefSeq (mRNA)	NM_000906	NM_008727
RefSeq (protein)	NP_000897	NP_032753
Location (UCSC)	Chr 1: 153.68 – 153.69 Mb	Chr 3: 90.45 – 90.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]

It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]

See also

• Atrial natriuretic peptide receptor

References

1. GRCh38: Ensembl release 89: ENSG00000169418 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027931 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
6. BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010, at the Wayback Machine

Further reading

• Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097.
• Lucarelli K, Iacoviello M, Dessì-Fulgheri P, et al. (2003). "[Natriuretic peptides and essential arterial hypertension]". Italian Heart Journal Supplement. 3 (11): 1085–91. PMID 12506509.
• Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides. 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067.
• Garg R, Pandey KN (2005). "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides. 26 (6): 1009–23. doi:10.1016/j.peptides.2004.09.022. PMID 15911069.

External links

• NPR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.