EPHB3

Ephrin type-B receptor 3 is a protein that in humans is encoded by the EPHB3 gene.[5][6]

EPHB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P1I, 3ZFY
Identifiers
Aliases	EPHB3, ETK2, HEK2, TYRO6, EPH receptor B3, EK2
External IDs	OMIM: 601839 MGI: 104770 HomoloGene: 20938 GeneCards: EPHB3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,561,785 bp[1] End 184,582,408 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B1 Start 21,204,755 bp[2] End 21,223,305 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • transmembrane receptor protein tyrosine kinase activity • protein kinase activity • kinase activity • ATP binding • transferase activity • ephrin receptor activity • axon guidance receptor activity • protein tyrosine kinase activity • receptor tyrosine kinase • transmembrane signaling receptor activity • transmembrane-ephrin receptor activity Cellular component • extracellular region • dendrite • integral component of membrane • cell projection • membrane • cytosol • cell membrane • integral component of plasma membrane • cytoplasm • neuron projection • receptor complex Biological process • phosphorylation • peptidyl-tyrosine phosphorylation • nervous system development • multicellular organism development • regulation of cell-cell adhesion • protein phosphorylation • substrate adhesion-dependent cell spreading • transmembrane receptor protein tyrosine kinase signaling pathway • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • autophosphorylation • angiogenesis • ephrin receptor signaling pathway • urogenital system development • axon guidance • axonal fasciculation • cell migration • central nervous system projection neuron axonogenesis • corpus callosum development • retinal ganglion cell axon guidance • thymus development • digestive tract morphogenesis • regulation of axonogenesis • positive regulation of synapse assembly • palate development • dendritic spine development • dendritic spine morphogenesis • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2049	13845
Ensembl	ENSG00000182580	ENSMUSG00000005958
UniProt	P54753	P54754
RefSeq (mRNA)	NM_004443	NM_010143
RefSeq (protein)	NP_004434	NP_034273
Location (UCSC)	Chr 3: 184.56 – 184.58 Mb	Chr 16: 21.2 – 21.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[6]

Interactions

EPHB3 has been shown to interact with MLLT4[7] and RAS p21 protein activator 1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000182580 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005958 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Böhme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rübsamen-Waigmann H (Oct 1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2". Oncogene. 8 (10): 2857–62. PMID 8397371.
6. "Entrez Gene: EPHB3 EPH receptor B3".
7. Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (Aug 1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
8. Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (Jul 1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development" (PDF). Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. S2CID 1278600.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 9780123646002. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. S2CID 205014301.
• Böhme B, VandenBos T, Cerretti DP, Park LS, Holtrich U, Rübsamen-Waigmann H, Strebhardt K (1996). "Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity". J. Biol. Chem. 271 (40): 24747–52. doi:10.1074/jbc.271.40.24747. PMID 8798744.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. S2CID 26773768.
• Bergemann AD, Zhang L, Chiang MK, Brambilla R, Klein R, Flanagan JG (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube". Oncogene. 16 (4): 471–80. doi:10.1038/sj.onc.1201557. PMID 9484836.
• Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K (1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions". Oncogene. 17 (2): 255–60. doi:10.1038/sj.onc.1201907. PMID 9674711.
• Hock B, Böhme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rübsamen-Waigmann H, Strebhardt K (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
• Ciossek T, Monschau B, Kremoser C, Löschinger J, Lang S, Müller BK, Bonhoeffer F, Drescher U (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci. 10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID 9751130. S2CID 20470923.
• Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R (1999). "Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis". Genes Dev. 13 (3): 295–306. doi:10.1101/gad.13.3.295. PMC 316426. PMID 9990854.

External links

• Overview of all the structural information available in the PDB for UniProt: P54753 (Ephrin type-B receptor 3) at the PDBe-KB.