NCAPH2

Condensin-2 complex subunit H2, also known as chromosome-associated protein H2 (CAP-H2) or non-SMC condensin II complex subunit H2 (NCAPH2), is a protein that in humans is encoded by the NCAPH2 gene.[5] CAP-H2 is a subunit of condensin II, a large protein complex involved in chromosome condensation.

NCAPH2
Identifiers
Aliases	NCAPH2, CAPH2, non-SMC condensin II complex subunit H2
External IDs	OMIM: 611230 MGI: 1289164 HomoloGene: 12045 GeneCards: NCAPH2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.33 Start 50,508,224 bp[1] End 50,524,780 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E3|15 44.84 cM Start 89,355,719 bp[2] End 89,372,826 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • chromatin binding Cellular component • membrane • chromosome • cell nucleus • nucleoplasm • cell junction • intercellular bridge • condensed chromosome • condensin complex Biological process • chromosome condensation • female meiotic nuclear division • meiotic chromosome condensation • T cell differentiation in thymus • chromosome organization • mitotic sister chromatid separation • female meiosis chromosome separation • mitotic chromosome condensation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29781	52683
Ensembl	ENSG00000025770	ENSMUSG00000008690
UniProt	Q6IBW4	Q8BSP2
RefSeq (mRNA)	NM_001185011 NM_014551 NM_152299	NM_001115132 NM_001271600 NM_001271601
RefSeq (protein)	NP_001171940 NP_055366 NP_689512	NP_001108604 NP_001258529 NP_001258530
Location (UCSC)	Chr 22: 50.51 – 50.52 Mb	Chr 15: 89.36 – 89.37 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000025770 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008690 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: non-SMC condensin II complex".

Further reading

• Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Ono T, Losada A, Hirano M, et al. (2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–21. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007.
• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Wood AJ, Severson AF, Meyer BJ (2010). "Condensin and cohesin complexity: the expanding repertoire of functions". Nat. Rev. Genet. 11 (6): 391–404. doi:10.1038/nrg2794. PMC 3491780. PMID 20442714.
• Schleiffer A, Kaitna S, Maurer-Stroh S, et al. (2003). "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners". Mol. Cell. 11 (3): 571–5. doi:10.1016/S1097-2765(03)00108-4. PMID 12667442.
• Kamatani Y, Matsuda K, Okada Y, et al. (2010). "Genome-wide association study of hematological and biochemical traits in a Japanese population". Nat. Genet. 42 (3): 210–5. doi:10.1038/ng.531. PMID 20139978.
• Collins JE, Wright CL, Edwards CA, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.