Gem-associated protein 6

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.[5][6] The gem-associated proteins are those found in the gems of Cajal bodies.

GEMIN6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Y96
Identifiers
Aliases	GEMIN6, gem nuclear organelle associated protein 6
External IDs	OMIM: 607006 MGI: 1914492 HomoloGene: 11711 GeneCards: GEMIN6
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.1 Start 38,751,534 bp[1] End 38,785,002 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 80,224,441 bp[2] End 80,228,497 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • SMN complex • SMN-Sm protein complex • cytosol • nuclear body • cell nucleus • nucleoplasm • Gemini of coiled bodies Biological process • mRNA splicing, via spliceosome • mRNA processing • spliceosomal complex assembly • RNA splicing • spliceosomal snRNP assembly • nuclear import Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79833	67242
Ensembl	ENSG00000152147	ENSMUSG00000055760
UniProt	Q8WXD5	Q9CX53
RefSeq (mRNA)	NM_024775	NM_026053 NM_001355458
RefSeq (protein)	NP_079051	NP_080329 NP_001342387
Location (UCSC)	Chr 2: 38.75 – 38.79 Mb	Chr 17: 80.22 – 80.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM][6]

Interactions

Gem-associated protein 6 has been shown to interact with gem-associated protein 7.[7][8]

References

1. GRCh38: Ensembl release 89: ENSG00000152147 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055760 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
6. "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
8. Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

Further reading

• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
• Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.