MRPL33

39S ribosomal protein L33, mitochondrial is a protein that in humans is encoded by the MRPL33 gene.[5]

MRPL33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL33, C2orf1, L33mt, MRP-L33, RPL33L, mitochondrial ribosomal protein L33
External IDs	OMIM: 610059 MGI: 2137225 HomoloGene: 81733 GeneCards: MRPL33
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 27,771,717 bp[1] End 27,988,087 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,596,935 bp[2] End 31,664,384 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of ribosome Cellular component • mitochondrial inner membrane • ribosome • intracellular • mitochondrion • mitochondrial large ribosomal subunit Biological process • mitochondrial translational elongation • mitochondrial translational termination • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9553	66845
Ensembl	ENSG00000243147	ENSMUSG00000106918
UniProt	O75394	Q9CQP0
RefSeq (mRNA)	NM_145330 NM_004891	NM_025796
RefSeq (protein)	NP_004882 NP_663303	NP_080072
Location (UCSC)	Chr 2: 27.77 – 27.99 Mb	Chr 5: 31.6 – 31.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000243147 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000106918 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MRPL33 mitochondrial ribosomal protein L33".

Further reading

• Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (June 2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". The Journal of Biological Chemistry. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

External links

• Overview of all the structural information available in the PDB for UniProt: O75394 (Human 39S ribosomal protein L33, mitochondrial (MRPL33)) at the PDBe-KB.