EIF4G3

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.[5][6] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.[7] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.[8]

EIF4G3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4G3, eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
External IDsOMIM: 603929 MGI: 1923935 HomoloGene: 2789 GeneCards: EIF4G3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.12Start20,806,292 bp[1]
End21,176,888 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8672

230861

Ensembl

ENSG00000075151

ENSMUSG00000028760

UniProt

O43432

Q80XI3

RefSeq (mRNA)

NM_001198801
NM_001198802
NM_001198803
NM_003760

NM_001256195
NM_001256198
NM_172703
NM_001355699
NM_001355700

RefSeq (protein)

NP_001185730
NP_001185731
NP_001185732
NP_003751

Location (UCSC)Chr 1: 20.81 – 21.18 MbChr 4: 137.99 – 138.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

EIF4G3 has been shown to interact with PABPC1.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000075151 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028760 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  6. "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".
  7. Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
  8. Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  9. Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.

Further reading


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