EIF4E2

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.[5][6][7] It belongs to the eukaryotic translation initiation factor 4E family.

EIF4E2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JGB, 2JGC
Identifiers
Aliases	EIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
External IDs	OMIM: 605895 MGI: 1914440 HomoloGene: 128466 GeneCards: EIF4E2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 232,550,674 bp[1] End 232,583,644 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 87,213,914 bp[2] End 87,240,488 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA cap binding • translation factor activity, RNA binding • GO:0001948 protein binding • translation initiation factor activity • ubiquitin protein ligase binding • RNA binding • RNA 7-methylguanosine cap binding Cellular component • cytoplasm • cytosol • mRNA cap binding complex • eukaryotic translation initiation factor 4F complex Biological process • translational initiation • negative regulation of translation • in utero embryonic development • protein biosynthesis • regulation of translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9470	26987
Ensembl	ENSG00000135930	ENSMUSG00000026254
UniProt	O60573	Q8BMB3
RefSeq (mRNA)	NM_001276336 NM_001276337 NM_001282958 NM_004846 NM_001330201 NM_001330202 NM_001330203	NM_001039169 NM_001039170 NM_023314 NM_001347083
RefSeq (protein)	NP_001263265 NP_001263266 NP_001269887 NP_001317130 NP_001317131 NP_001317132 NP_004837	NP_001034258 NP_001034259 NP_001334012 NP_075803
Location (UCSC)	Chr 2: 232.55 – 232.58 Mb	Chr 1: 87.21 – 87.24 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

EIF4E2 has been shown to interact with ARIH1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000135930 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026254 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
6. Rom E, Kim HC, Gingras AC, Marcotrigiano J, Favre D, Olsen H, Burley SK, Sonenberg N (Jun 1998). "Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein". J. Biol. Chem. 273 (21): 13104–9. doi:10.1074/jbc.273.21.13104. PMID 9582349.
7. "Entrez Gene: EIF4E2 eukaryotic translation initiation factor 4E family member 2".
8. Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (Nov 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.

Further reading

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Tan NG, Ardley HC, Scott GB, Rose SA, Markham AF, Robinson PA (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. doi:10.1016/S0014-5793(03)01235-3. PMID 14623119. S2CID 25441190.
• Tee AR, Tee JA, Blenis J (2004). "Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1". FEBS Lett. 564 (1–2): 58–62. doi:10.1016/S0014-5793(04)00313-8. PMID 15094042. S2CID 32997726.
• Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Okumura F, Zou W, Zhang DE (2007). "ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP". Genes Dev. 21 (3): 255–60. doi:10.1101/gad.1521607. PMC 1785121. PMID 17289916.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rosettani P, Knapp S, Vismara MG, Rusconi L, Cameron AD (2007). "Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms". J. Mol. Biol. 368 (3): 691–705. doi:10.1016/j.jmb.2007.02.019. PMID 17368478.
• Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E (2007). "Weak binding affinity of human 4EHP for mRNA cap analogs". RNA. 13 (5): 691–7. doi:10.1261/rna.453107. PMC 1852817. PMID 17369309.

External links

• Overview of all the structural information available in the PDB for UniProt: O60573 (Eukaryotic translation initiation factor 4E type 2) at the PDBe-KB.