Interstitial collagenase
Interstitial collagenase (EC 3.4.24.7, vertebrate collagenase, matrix metalloproteinase 1) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
| Interstitial collagenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 collagenase monomer, Human fibroblast | |||||||||
| Identifiers | |||||||||
| EC number | 3.4.24.7 | ||||||||
| CAS number | 2593923 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme belongs to the peptidase family M10.
See also
References
- Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ (May 1986). "Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein". The Journal of Biological Chemistry. 261 (14): 6600–5. PMID 3009463.
- Birkedal-Hansen H (1987). "Catabolism and turnover of collagens: collagenases". Methods in Enzymology. 144: 140–71. doi:10.1016/0076-6879(87)44177-3. PMID 3041177.
- Fields GB, Van Wart HE, Birkedal-Hansen H (May 1987). "Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site". The Journal of Biological Chemistry. 262 (13): 6221–6. PMID 3032960.
- Sottrup-Jensen L, Birkedal-Hansen H (January 1989). "Human fibroblast collagenase-alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins". The Journal of Biological Chemistry. 264 (1): 393–401. PMID 2462561.
External links
- Interstitial+collagenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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