ADAM18

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[5][6]

ADAM18
Identifiers
Aliases	ADAM18, ADAM27, tMDCIII, ADAM metallopeptidase domain 18
External IDs	MGI: 105986 HomoloGene: 74941 GeneCards: ADAM18
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 39,584,489 bp[1] End 39,730,065 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A2 Start 24,602,246 bp[2] End 24,674,755 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metalloendopeptidase activity • metallopeptidase activity Cellular component • integral component of membrane • membrane Biological process • multicellular organism development • cell differentiation • spermatogenesis • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8749	13524
Ensembl	ENSG00000168619 ENSG00000278548	ENSMUSG00000031552
UniProt	Q9Y3Q7	Q9R157
RefSeq (mRNA)	NM_001190956 NM_014237 NM_001320313	NM_010084
RefSeq (protein)	NP_001177885 NP_001307242 NP_055052	NP_034214
Location (UCSC)	Chr 8: 39.58 – 39.73 Mb	Chr 8: 24.6 – 24.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[6]

References

1. ENSG00000278548 GRCh38: Ensembl release 89: ENSG00000168619, ENSG00000278548 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031552 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod. 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459.
6. "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". Gene. 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
• Frayne J, Jury JA, Barker HL, et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.957
• Human ADAM18 genome location and ADAM18 gene details page in the UCSC Genome Browser.