ADAMTS10

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[5]

ADAMTS10
Identifiers
Aliases	ADAMTS10, ADAM-TS10, ADAMTS-10, WMS, WMS1, ADAM metallopeptidase with thrombospondin type 1 motif 10
External IDs	OMIM: 608990 MGI: 2449112 HomoloGene: 81940 GeneCards: ADAMTS10
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 8,580,240 bp[1] End 8,610,735 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 33,524,204 bp[2] End 33,553,782 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • metalloendopeptidase activity • GO:0001948 protein binding • hydrolase activity • metallopeptidase activity • metal ion binding • molecular function Cellular component • microfibril • extracellular region • extracellular matrix • collagen-containing extracellular matrix Biological process • proteolysis • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81794	224697
Ensembl	ENSG00000142303	ENSMUSG00000024299
UniProt	Q9H324	P58459
RefSeq (mRNA)	NM_001282352 NM_030957	NM_172619 NM_001329143 NM_001329147 NM_001329151 NM_001329152 NM_001329153 NM_001329154 NM_001329202 NM_001329203
RefSeq (protein)	NP_001269281 NP_112219	NP_001316072 NP_001316076 NP_001316080 NP_001316081 NP_001316082 NP_001316083 NP_001316131 NP_001316132 NP_766207
Location (UCSC)	Chr 19: 8.58 – 8.61 Mb	Chr 17: 33.52 – 33.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000142303 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024299 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10".

Further reading

• Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases". Int. J. Biochem. Cell Biol. 33 (1): 33–44. doi:10.1016/S1357-2725(00)00061-3. PMID 11167130.
• Faivre L, Dollfus H, Lyonnet S, et al. (2004). "Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome". Am. J. Med. Genet. A. 123 (2): 204–7. doi:10.1002/ajmg.a.20289. PMID 14598350. S2CID 13600027.
• Apte SS (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family". Int. J. Biochem. Cell Biol. 36 (6): 981–5. doi:10.1016/j.biocel.2004.01.014. PMID 15094112.
• Faivre L, Mégarbané A, Alswaid A, et al. (2002). "Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2". Hum. Genet. 110 (4): 366–70. doi:10.1007/s00439-002-0689-3. PMID 11941487. S2CID 10463979.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Somerville RP, Jungers KA, Apte SS (2005). "Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation". J. Biol. Chem. 279 (49): 51208–17. doi:10.1074/jbc.M409036200. PMID 15355968.
• Charrier L, Yan Y, Driss A, et al. (2005). "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G346–53. doi:10.1152/ajpgi.00262.2004. PMID 15358598.
• Dagoneau N, Benoist-Lasselin C, Huber C, et al. (2005). "ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome". Am. J. Hum. Genet. 75 (5): 801–6. doi:10.1086/425231. PMC 1182109. PMID 15368195.

External links

• GeneReviews/NIH/NCBI/UW entry on Weill-Marchesani Syndrome
• The MEROPS online database for peptidases and their inhibitors: M12.235
• Human ADAMTS10 genome location and ADAMTS10 gene details page in the UCSC Genome Browser.