Integrin beta 3

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[5] CD61 is a cluster of differentiation found on thrombocytes.[6]

ITGB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
Identifiers
Aliases	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3
External IDs	OMIM: 173470 MGI: 96612 HomoloGene: 55444 GeneCards: ITGB3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,253,846 bp[1] End 47,313,735 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 67.84 cM Start 104,608,000 bp[2] End 104,670,476 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • vascular endothelial growth factor receptor 2 binding • fibronectin binding • virus receptor activity • extracellular matrix binding • protein disulfide isomerase activity • protease binding • platelet-derived growth factor receptor binding • GO:0001948 protein binding • identical protein binding • enzyme binding • cell adhesion molecule binding • neuregulin binding • coreceptor activity • fibroblast growth factor binding • insulin-like growth factor I binding • C-X3-C chemokine binding • integrin binding • fibrinogen binding Cellular component • integral component of membrane • cell projection • alphav-beta3 integrin-vitronectin complex • membrane • focal adhesion • melanosome • receptor complex • cell membrane • integral component of plasma membrane • ruffle membrane • cell surface • cell junction • integrin complex • platelet alpha granule membrane • integrin alphav-beta3 complex • extracellular exosome • lamellipodium membrane • cell nucleus • microvillus membrane • filopodium membrane • alphav-beta3 integrin-IGF-1-IGF1R complex • alphav-beta3 integrin-PKCalpha complex • alphav-beta3 integrin-HMGB1 complex • glutamatergic synapse • synapse Biological process • negative regulation of lipoprotein metabolic process • apolipoprotein A-I-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of protein phosphorylation • regulation of cell migration • negative chemotaxis • positive regulation of endothelial cell proliferation • tube development • heterotypic cell-cell adhesion • angiogenesis involved in wound healing • wound healing • platelet degranulation • blood coagulation • extracellular matrix organization • smooth muscle cell migration • positive regulation of endothelial cell migration • cell growth • cell-substrate adhesion • vascular endothelial growth factor receptor signaling pathway • cell adhesion • positive regulation of peptidyl-tyrosine phosphorylation • mesodermal cell differentiation • cell-substrate junction assembly • integrin-mediated signaling pathway • negative regulation of lipid storage • substrate adhesion-dependent cell spreading • negative regulation of lipid transport • cell-matrix adhesion • GO:0022415 viral process • regulation of bone resorption • platelet aggregation • cell migration • negative regulation of macrophage derived foam cell differentiation • activation of protein kinase activity • leukocyte migration • cell adhesion mediated by integrin • platelet activation • apoptotic cell clearance • regulation of postsynaptic neurotransmitter receptor internalization • regulation of protein localization • regulation of serotonin uptake Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3690	16416
Ensembl	ENSG00000259207	ENSMUSG00000020689
UniProt	P05106	O54890
RefSeq (mRNA)	NM_000212	NM_016780
RefSeq (protein)	NP_000203	NP_058060
Location (UCSC)	Chr 17: 47.25 – 47.31 Mb	Chr 11: 104.61 – 104.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.[7]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.[8]

Interactions

CD61 has been shown to interact with PTK2,[9][10] ITGB3BP,[11][12] TLN1[13][14] and CIB1.[15]

See also

• Glycoprotein IIb/IIIa

References

1. GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (August 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
6. Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. (2013). "Platelet-based coagulation: different populations, different functions". Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. ISSN 1538-7933. PMID 23106920. S2CID 206157070.
7. "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".
8. May, K. E.; Villar, J.; Kirtley, S.; Kennedy, S. H.; Becker, C. M. (2011). "Endometrial alterations in endometriosis: A systematic review of putative biomarkers". Human Reproduction Update. 17 (5): 637–653. doi:10.1093/humupd/dmr013. PMID 21672902.
9. Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (April 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
10. Chung, J; Gao A G; Frazier W A (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. 272 (23): 14740–6. doi:10.1074/jbc.272.23.14740. ISSN 0021-9258. PMID 9169439.
11. Fujimoto, Tetsuro-Takahiro; Katsutani Shinya; Shimomura Takeshi; Fujimura Kingo (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. ISSN 0049-3848. PMID 11864709.
12. Shattil, S J; O'Toole T; Eigenthaler M; Thon V; Williams M; Babior B M; Ginsberg M H (November 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J. Cell Biol. 131 (3): 807–16. doi:10.1083/jcb.131.3.807. ISSN 0021-9525. PMC 2120613. PMID 7593198.
13. Patil, S; Jedsadayanmata A; Wencel-Drake J D; Wang W; Knezevic I; Lam S C (October 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. 274 (40): 28575–83. doi:10.1074/jbc.274.40.28575. ISSN 0021-9258. PMID 10497223.
14. Calderwood, David A; Yan Boxu; de Pereda Jose M; Alvarez Begoña García; Fujioka Yosuke; Liddington Robert C; Ginsberg Mark H (June 2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. 277 (24): 21749–58. doi:10.1074/jbc.M111996200. ISSN 0021-9258. PMID 11932255.
15. Naik, U P; Patel P M; Parise L V (February 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. 272 (8): 4651–4. doi:10.1074/jbc.272.8.4651. ISSN 0021-9258. PMID 9030514.

Further reading

• Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost. 72 (4): 492–502. PMID 7878622.
• Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci. 936 (1): 340–54. Bibcode:2001NYASA.936..340B. doi:10.1111/j.1749-6632.2001.tb03521.x. PMID 11460491. S2CID 25431334.
• Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187–93. doi:10.1055/s-0037-1612971. PMID 11858476.
• Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945–52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease". Italian Heart Journal. 4 (1): 17–22. PMID 12690916.
• Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease". Thromb. Res. 112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.
• Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): 1567–76. doi:10.2174/1381612043384682. PMID 15134555.
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments". Curr. Med. Chem. 12 (1): 51–70. doi:10.2174/0929867053363522. PMID 15638730.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets". J. Thromb. Haemost. 3 (8): 1752–62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042. S2CID 42666713.
• Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3". J. Clin. Invest. 115 (12): 3363–9. doi:10.1172/JCI26989. PMC 1297263. PMID 16322781.

External links

• CD61+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGB3 Info with links in the Cell Migration Gateway
• Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.