CD180

CD180 antigen is a protein that in humans is encoded by the CD180 gene.[4][5][6][7]

CD180
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B2D
Identifiers
Aliases	CD180, LY64, Ly78, RP105, CD180 molecule
External IDs	OMIM: 602226 MGI: 1194924 HomoloGene: 4077 GeneCards: CD180
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q12.3 Start 67,179,613 bp[1] End 67,196,799 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • extracellular • extracellular matrix Biological process • positive regulation of lipopolysaccharide-mediated signaling pathway • innate immune system • cellular response to lipopolysaccharide • B cell proliferation involved in immune response • immune system process • toll-like receptor signaling pathway • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4064	17079
Ensembl	ENSG00000134061	ENSMUSG00000021624
UniProt	Q99467	Q62192
RefSeq (mRNA)	NM_005582	NM_008533 NM_001360519
RefSeq (protein)	NP_005573	NP_032559 NP_001347448
Location (UCSC)	Chr 5: 67.18 – 67.2 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. It is also known by the archaic terms Bgp-95 and RP105, for the founding designations following discovery in humans (1988) and mice (1994), respectively. CD180 is expressed on antigen presenting cells including B cells and dendritic cells. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, CD180/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.[6]

Recently, CD180 has been demonstrated to be involved in the survival and prognosis of B-cell chronic lymphocytic leukemia.[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000134061 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (Nov 1998). "RP105 is associated with MD-1 and transmits an activation signal in human B cells". Blood. 92 (8): 2815–22. doi:10.1182/blood.V92.8.2815. PMID 9763566.
5. Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (Mar 1997). "Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)". Genomics. 38 (3): 299–304. doi:10.1006/geno.1996.0632. PMID 8975706.
6. "Entrez Gene: CD180 CD180 molecule".
7. [4]
8. Porakishvili, Nino; Memon, Azka; Vispute, Ketki; Kulikova, Nina; Clark, Edward A.; Rai, Kanti R.; Nathwani, Amit; Damle, Rajendra N.; Chiorazzi, Nicholas; Lydyard, Peter M. (May 2011). "CD180 functions in activation, survival and cycling of B chronic lymphocytic leukaemia cells". British Journal of Haematology. 153 (4): 486–498. doi:10.1111/j.1365-2141.2011.08605.x. ISSN 0007-1048. PMID 21443749. S2CID 13360804.
9. Gordiienko, Inna; Shlapatska, Larysa; Kholodniuk, Valeriia; Sklyarenko, Lilia; Gluzman, Daniel F.; Clark, Edward A.; Sidorenko, Svetlana P. (2017-10-05). "The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling". PLOS ONE. 12 (10): e0185940. Bibcode:2017PLoSO..1285940G. doi:10.1371/journal.pone.0185940. ISSN 1932-6203. PMC 5628907. PMID 28982149.

Further reading

• Honda Y, Yamagiwa S, Matsuda Y, et al. (2007). "Altered expression of TLR homolog RP105 on monocytes hypersensitive to LPS in patients with primary biliary cirrhosis". J. Hepatol. 47 (3): 404–11. doi:10.1016/j.jhep.2007.03.012. PMID 17448566.
• Divanovic S, Trompette A, Atabani SF, et al. (2005). "Negative Regulation of TLR4 Signaling by RP105". Nat. Immunol. 6 (6): 571–8. doi:10.1038/ni1198. PMC 2144914. PMID 15852007.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Miyake K, Shimazu R, Kondo J, et al. (1998). "Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression". J. Immunol. 161 (3): 1348–53. PMID 9686597.

External links

• Human CD180 genome location and CD180 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q99467 (Human CD180 antigen) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q62192 (Mouse CD180 antigen) at the PDBe-KB.