HLA-B53

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)

major histocompatibility complex (human), class I, B53
Alleles B*5301
B*5302
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5301
EBI-HLA B*5302
Locus chr.6 6p21.31

Serotype
B53 and B35 serotype recognition of Some HLA B*35 allele-group gene products[3]
B*53B53 B35Sample
allele%%size (N)
53018653054
530280205

B*5301 allele frequencies
HLA B*7801 frequencies
freq
ref.Population(%)
[4]Akan Adiopodoume (Ivory Coast)22.7
[4]Rimaibe (Burkina Faso)22.3
[4]Mossi (Burkina Faso)20.8
[4]Bandiagara (Mali)15.9
[4]Sawa (Cameroon)11.5
[4]Lusaka (Zambia)10.2
[4]Baka Pygmy (Cameroon)10.0
[4]Guinea Bissau10.0
[4]Harare Shona (Zimbabwe)9.3
[4]Baloch (Iran)9.1
[4]Kenya8.7
[4]Canoncito Navajo (USA)8.5
[4]Brahui (Pakistan)7.7
[4]Niokholo Mandenka (Senegal)5.3
[4]Croatia (2)5.0
[4]Mongolia Khoton Tarialan4.9
[4]Pakistan Baloch4.6
[4]Casablanca (Morocco)3.7
[4]Arratia Basque (Spain)3.3
[4]Crete (Greece)3.2
[4]Israel Arab Druse2.5
[4]Israel Gaza Palestinians2.4
[4]Amman (Jordan )2.4
[4]Tunis (Tunisia )2.3
[4]Tuva (2) (Russia)2.2
[4]Oman2.1
[4]France South East1.6
[4]Saudi Arabia Guraiat and Hail1.5
[4]Berber (Morocco)1.4
[4]Georgia Svaneti Svans1.3
[4]Mongolia Khalkh Ulaanbaatar1.2
[4]Spain Catalonia Girona1.1
[4]India Andhra Pradesh Golla1.0
[4]Mongolia Khalha1.0

Haplotype frequencies
A*3601 : Cw*0401 : B*5301
freq
ref.Population(%)
Zimbabwe3.6
[4]Zambia Lusaka2.3
N. Afr. Negroid2.1
[4]Kenya Luo1.9
[4]Cameroon Yaounde1.7
[5]African American1.5
[4]Kenya Nandi1.3
[5]American Hispanic0.2
'
A*6802 : Cw*0401 : B*5301
[4]Mali Bandihagara2.7
[5]African American1.4
[4]Kenya Nandi1.0
[5]Hispanic American0.6
[5]Caucasian American0.2

Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in African Americans.

References
  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. Allsopp CE, Hill AV, Kwiatkowski D, et al. (1991). "Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35". Hum. Immunol. 30 (2): 105–9. doi:10.1016/0198-8859(91)90078-N. PMID 2022493.
  3. derived from IMGT/HLA
  4. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)
  5. Maiers M, Gragert L, Klitz W (2007). "High-resolution HLA alleles and haplotypes in the United States population". Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.
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