GPR112

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene.[5][6] GPR112 is a member of the adhesion GPCR family.[7][8] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[9]

ADGRG4
Identifiers
AliasesADGRG4, PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4
External IDsMGI: 2685213 HomoloGene: 72131 GeneCards: ADGRG4
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq26.3Start136,300,963 bp[1]
End136,416,890 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

139378

236798

Ensembl

ENSG00000156920

ENSMUSG00000053852

UniProt

Q8IZF6

n/a

RefSeq (mRNA)

NM_153834

NM_001033327
NM_001110790
NM_001362885

RefSeq (protein)

NP_722576

n/a

Location (UCSC)Chr X: 136.3 – 136.42 MbChr X: 56.87 – 57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GPR112 is expressed in human enterochromaffin cells[10] and in the mouse intestine.[11] The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules.[11] GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.[10]

References
  1. GRCh38: Ensembl release 89: ENSG00000156920 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053852 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GPR112 G protein-coupled receptor 112".
  6. Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  7. Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3.
  8. Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165.
  9. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  10. Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V (Feb 2009). "Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas". Modern Pathology. 22 (2): 261–72. doi:10.1038/modpathol.2008.174. PMID 18953328.
  11. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T, Schiöth HB (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–67. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
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