Allylglycine

Allylglycine is a glycine derivative. It is an inhibitor of glutamate decarboxylase.[2] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[3] Allylglycine is known to induce seizures in animals studies, presumably due to this GDC-inhibiting activity.[4]

Allylglycine

Names
Preferred IUPAC name 2-Aminopent-4-enoic acid
Identifiers
CAS Number	7685-44-1
3D model (JSmol)	Interactive image Interactive image
ChemSpider	13425
ECHA InfoCard	100.028.809
PubChem CID	14044
InChI InChI=1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8) Key: WNNNWFKQCKFSDK-UHFFFAOYSA-N InChI=1/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8) Key: WNNNWFKQCKFSDK-UHFFFAOYAL
SMILES C=CCC(C(=O)O)N O=C(O)C(N)CC=C
Properties
Chemical formula	C5H9NO2
Molar mass	115.13 g/mol
Appearance	white crystalline powder
Density	1.098 g/mL
Melting point	265 °C (509 °F; 538 K)
Boiling point	231 °C (448 °F; 504 K)
Hazards
Main hazards	Convulsant
Lethal dose or concentration (LD, LC):
LD50 (median dose)	147-195 mg/kg (mice)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

See also

• 3-Mercaptopropionic acid

References

1. Piepho, R. W; Friedman, A. H (1977). "Chronopharmacology of Strychnine and Allylglycine in the Mouse". Clinical and Experimental Pharmacology and Physiology. 4 (3): 263–6. doi:10.1111/j.1440-1681.1977.tb02623.x. PMID 891041. S2CID 25088608.
2. Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383. S2CID 32655173.
3. Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMC 3065212. PMID 18308797.
4. Thomas J, Yang YC (June 1991). "Allylglycine induced seizures in male and female rats". Physiol. Behav. 49 (6): 1181–3. doi:10.1016/0031-9384(91)90348-R. PMID 1654571. S2CID 10506822.