6-Hydroxyflavone

6-Hydroxyflavone
Names
	IUPAC name 6-hydroxy-2-phenylchromen-4-one
	Other names 6-Monohydroxyflavone; 6-Hydroxy-2-phenyl-4-benzopyrone
Identifiers
CAS Number	6665-83-4 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL138649 ;
ChemSpider	65233 ;
ECHA InfoCard	100.027.005
EC Number	229-704-8;
KEGG	C14137 ;
PubChem CID	72279;
UNII	148S6Z78H6 ;
CompTox Dashboard (EPA)	DTXSID8022327 ;
	InChI InChI=1S/C15H10O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9,16H Key: GPZYYYGYCRFPBU-UHFFFAOYSA-N ; InChI=1/C15H10O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9,16H Key: GPZYYYGYCRFPBU-UHFFFAOYAV;
	SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=CC(=C3)O; O=C\1c3c(O/C(=C/1)c2ccccc2)ccc(O)c3;
Properties
Chemical formula	C15H10O3
Molar mass	238.242 g·mol−1
Melting point	234 to 236 °C (453 to 457 °F; 507 to 509 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

6-Hydroxyflavone is a flavone, a type of chemical compound. It is one of the noncompetitive inhibitors of cytochrome P450 2C9. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India).[1] 6-Hydroxyflavone may have a potential as a therapeutic drug capable for the treatment of anxiety-like disorders.[2][3]

References

M Daniel (2006). Medicinal Plants: Chemistry and Properties. Science Publishers. p. 78. ISBN 978-1-57808-395-4.
Ren, Lihuan; Wang, Feng; Xu, Zhiwen; Chan, Wing Man; Zhao, Cunyou; Xue, Hong (2010), "GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone", Biochemical Pharmacology, 79 (9): 1337–1344, doi:10.1016/j.bcp.2009.12.024, PMID 20067772
"6-HYDROXYFLAVONE | CAS:6665-83-4 | Huateng Pharma | Pharmaceutical chemical reagents, PEG derivatives". en.huatengsci.com. Retrieved 27 March 2020.

External links

6-hydroxy flavone on Plant Metabolic Network

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[1] M Daniel (2006). Medicinal Plants: Chemistry and Properties. Science Publishers. p. 78. ISBN 978-1-57808-395-4.

[2] Ren, Lihuan; Wang, Feng; Xu, Zhiwen; Chan, Wing Man; Zhao, Cunyou; Xue, Hong (2010), "GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone", Biochemical Pharmacology, 79 (9): 1337–1344, doi:10.1016/j.bcp.2009.12.024, PMID 20067772

[3] "6-HYDROXYFLAVONE | CAS:6665-83-4 | Huateng Pharma | Pharmaceutical chemical reagents, PEG derivatives". en.huatengsci.com. Retrieved 27 March 2020.