VUF-8430

VUF-8430 is a histamine agonist[1] selective for the H₄ subtype.[2]

VUF-8430

Names
Preferred IUPAC name 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester
Identifiers
CAS Number	98021-17-1
3D model (JSmol)	Interactive image
Abbreviations	VUF-8430
ChEMBL	ChEMBL1196470
ChemSpider	2323820
IUPHAR/BPS	1274
PubChem CID	3063228
InChI InChI=1S/C4H11N5S/c5-3(6)9-1-2-10-4(7)8/h1-2H2,(H3,7,8)(H4,5,6,9) Key: GSYGTVNTZHFQQH-UHFFFAOYSA-N
SMILES NC(=N)NCCSC(N)=N
Properties
Chemical formula	C4H11N5S
Molar mass	161.23 g·mol^−1
log P	-1.367
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References

1. Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). "Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury". Neuroimmunomodulation. 14 (6): 317–25. doi:10.1159/000125048. PMID 18401194.
2. Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). "Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist". Journal of Medicinal Chemistry. 49 (23): 6650–1. doi:10.1021/jm060880d. PMID 17154494.