TSPAN3

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.[5]

TSPAN3
Identifiers
Aliases	TSPAN3, TM4-A, TM4SF8, TSPAN-3, tetraspanin 3
External IDs	OMIM: 613134 MGI: 1928098 HomoloGene: 21168 GeneCards: TSPAN3
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.3 Start 77,041,404 bp[1] End 77,083,984 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 56,131,725 bp[2] End 56,165,477 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • molecular function Cellular component • integral component of membrane • integral component of plasma membrane • extracellular exosome • membrane Biological process • cell surface receptor signaling pathway • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10099	56434
Ensembl	ENSG00000140391	ENSMUSG00000032324
UniProt	O60637	Q9QY33
RefSeq (mRNA)	NM_198902 NM_001168412 NM_005724	NM_019793
RefSeq (protein)	NP_001161884 NP_005715 NP_944492	NP_062767
Location (UCSC)	Chr 15: 77.04 – 77.08 Mb	Chr 9: 56.13 – 56.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Two alternative transcripts encoding different isoforms have been described.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000140391 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032324 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TSPAN3 tetraspanin 3".

Further reading

• Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. PMID 11739647.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Todd SC, Doctor VS, Levy S (1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim. Biophys. Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
• Wu YJ, Noguchi CT (1991). "Activation of globin gene expression by cDNAs from induced K562 cells. Evidence for involvement of ferritin in globin gene expression". J. Biol. Chem. 266 (26): 17566–72. PMID 1840594.

External links

• TSPAN3 human gene location in the UCSC Genome Browser.
• TSPAN3 human gene details in the UCSC Genome Browser.