TSPAN2

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.[5][6][7]

TSPAN2
Identifiers
Aliases	TSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDs	OMIM: 613133 MGI: 1917997 HomoloGene: 21169 GeneCards: TSPAN2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 115,048,011 bp[1] End 115,089,503 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 102,734,529 bp[2] End 102,801,513 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • myelin • cell membrane • integral component of plasma membrane • membrane Biological process • astrocyte development • myelination • cell surface receptor signaling pathway • axon development • brain development • oligodendrocyte differentiation • inflammatory response • microglia development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10100	70747
Ensembl	ENSG00000134198	ENSMUSG00000027858
UniProt	O60636	Q922J6
RefSeq (mRNA)	NM_001308315 NM_001308316 NM_005725	NM_001243132 NM_027533
RefSeq (protein)	NP_001295244 NP_001295245 NP_005716	NP_001230061 NP_081809
Location (UCSC)	Chr 1: 115.05 – 115.09 Mb	Chr 3: 102.73 – 102.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027858 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
6. Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci. 114 (Pt 23): 4143–51. PMID 11739647.
7. "Entrez Gene: TSPAN2 tetraspanin 2".

Further reading

• Hemler ME (2002). "Specific tetraspanin functions". J. Cell Biol. 155 (7): 1103–7. doi:10.1083/jcb.200108061. PMC 2199333. PMID 11756464.
• Gregory SG; Barlow KF; McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• TSPAN2 human gene location in the UCSC Genome Browser.
• TSPAN2 human gene details in the UCSC Genome Browser.