SNRPB2

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[4][5]

SNRPB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9N
Identifiers
Aliases	SNRPB2, Msl1, U2B, small nuclear ribonucleoprotein polypeptide B2
External IDs	OMIM: 603520 MGI: 104805 HomoloGene: 37728 GeneCards: SNRPB2
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.1 Start 16,729,961 bp[1] End 16,742,564 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleic acid binding • snRNA stem-loop binding • GO:0001948 protein binding • RNA binding • snRNP binding • U1 snRNA binding Cellular component • catalytic step 2 spliceosome • spliceosomal complex • U2 snRNP • small nuclear ribonucleoprotein complex • fibrillar center • nucleoplasm • nuclear speck • U1 snRNP • U2-type catalytic step 2 spliceosome • cell nucleus • U2-type precatalytic spliceosome Biological process • mRNA processing • RNA splicing • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6629	20639
Ensembl	ENSG00000125870	ENSMUSG00000008333
UniProt	P08579	Q9CQI7
RefSeq (mRNA)	NM_198220 NM_003092	NM_021335
RefSeq (protein)	NP_003083 NP_937863	NP_067310
Location (UCSC)	Chr 20: 16.73 – 16.74 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000125870 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. doi:10.1073/pnas.84.8.2421. PMC 304663. PMID 2951739.
5. "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".

Further reading

• Feeney RJ, Zieve GW (1990). "Nuclear exchange of the U1 and U2 snRNP-specific proteins". J. Cell Biol. 110 (4): 871–81. doi:10.1083/jcb.110.4.871. PMC 2116108. PMID 2139037.
• Laitinen J, Saris P, Hölttä E, Pettersson I (1995). "U2-snRNP B" protein gene is an early growth-inducible gene". J. Cell. Biochem. 58 (4): 490–8. doi:10.1002/jcb.240580412. PMID 7593271. S2CID 24548645.
• Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E." Nucleic Acids Res. 25 (2): 354–61. doi:10.1093/nar/25.2.354. PMC 146436. PMID 9016565.
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
• Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles". Biochem. J. 332 (1): 135–44. doi:10.1042/bj3320135. PMC 1219461. PMID 9576861.
• Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. doi:10.1038/29234. PMID 9716128. S2CID 204999419.
• Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529. S2CID 585778.
• Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
• Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II". J. Cell Biol. 152 (1): 75–85. doi:10.1083/jcb.152.1.75. PMC 2193649. PMID 11149922.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. S2CID 1518837.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Chung S, Zhou Z, Huddleston KA, et al. (2002). "Crooked neck is a component of the human spliceosome and implicated in the splicing process". Biochim. Biophys. Acta. 1576 (3): 287–97. doi:10.1016/S0167-4781(02)00368-8. PMID 12084575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.