Postpartum infections

Postpartum infections, also known as childbed fever and puerperal fever, are any bacterial infections of the female reproductive tract following childbirth or miscarriage.[1] Signs and symptoms usually include a fever greater than 38.0 °C (100.4 °F), chills, lower abdominal pain, and possibly bad-smelling vaginal discharge.[1] It usually occurs after the first 24 hours and within the first ten days following delivery.[5]

Postpartum infections
Other namesPuerperal fever, childbed fever, maternal sepsis, maternal infection, puerperal infections
Streptococcus pyogenes (red-stained spheres) is responsible for many cases of severe puerperal fever. (900× magnification)
SpecialtyObstetrics
SymptomsFever, lower abdominal pain, bad-smelling vaginal discharge[1]
CausesTypically multiple types of bacteria[1]
Risk factorsCesarean section, premature rupture of membranes, prolonged labour, malnutrition, diabetes[1][2]
TreatmentAntibiotics[1]
Frequency11.8 million[3]
Deaths17,900[4]

The most common infection is that of the uterus and surrounding tissues known as puerperal sepsis, postpartum metritis, or postpartum endometritis.[1][6] Risk factors include Caesarean section (C-section), the presence of certain bacteria such as group B streptococcus in the vagina, premature rupture of membranes, multiple vaginal exams, manual removal of the placenta, and prolonged labour among others.[1][2] Most infections involve a number of types of bacteria.[1] Diagnosis is rarely helped by culturing of the vagina or blood.[1] In those who do not improve, medical imaging may be required.[1] Other causes of fever following delivery include breast engorgement, urinary tract infections, infections of an abdominal incision or an episiotomy, and atelectasis.[1][2]

Due to the risks following Caesarean section, it is recommended that all women receive a preventive dose of antibiotics such as ampicillin around the time of surgery.[1] Treatment of established infections is with antibiotics, with most people improving in two to three days.[1] In those with mild disease, oral antibiotics may be used; otherwise intravenous antibiotics are recommended.[1] Common antibiotics include a combination of ampicillin and gentamicin following vaginal delivery or clindamycin and gentamicin in those who have had a C-section.[1] In those who are not improving with appropriate treatment, other complications such an abscess should be considered.[1]

In 2015, about 11.8 million maternal infections occurred.[3] In the developed world about one to two percent develop uterine infections following vaginal delivery.[1] This increases to five to thirteen percent among those who have more difficult deliveries and 50 percent with C-sections before the use of preventive antibiotics.[1] In 2015, these infections resulted in 17,900 deaths down from 34,000 deaths in 1990.[4][7] They are the cause of about 10% of deaths around the time of pregnancy.[2] The first known descriptions of the condition date back to at least the 5th century BCE in the writings of Hippocrates.[8] These infections were a very common cause of death around the time of childbirth starting in at least the 18th century until the 1930s when antibiotics were introduced.[9] In 1847, Hungarian physician Ignaz Semmelweiss decreased death from the disease in the First Obstetrical Clinic of Vienna from nearly twenty percent to two percent through the use of handwashing with calcium hypochlorite.[10][11]

Signs and symptoms

Signs and symptoms usually include a fever greater than 38.0 °C (100.4 °F), chills, low abdominal pain, and possibly bad smelling vaginal discharge.[1] It usually occurs after the first 24 hours and within the first ten days following delivery.[5]

Causes

After childbirth a woman's genital tract has a large bare surface, which is prone to infection. Infection may be limited to the cavity and wall of her uterus, or it may spread beyond to cause septicaemia (blood poisoning) or other illnesses, especially when her resistance has been lowered by a long labour or severe bleeding. Puerperal infection is most common on the raw surface of the interior of the uterus after separation of the placenta (afterbirth); but pathogenic organisms may also affect lacerations of any part of the genital tract. By whatever portal, they can invade the bloodstream and lymph system to cause sepsis, cellulitis (inflammation of connective tissue), and pelvic or generalized peritonitis (inflammation of the abdominal lining). The severity of the illness depends on the virulence of the infecting organism, the resistance of the invaded tissues, and the general health of the woman. Organisms commonly producing this infection are Streptococcus pyogenes; staphylococci (inhabitants of the skin and of pimples, carbuncles, and many other pustular eruptions); the anaerobic streptococci, which flourish in devitalized tissues such as may be present after long and injurious labour and unskilled instrumental delivery; Escherichia coli and Clostridium perfringens (inhabitants of the lower bowel); and Clostridium tetani.

Risk factors

Causes (listed in order of decreasing frequency) include endometritis, urinary tract infection, pneumonia/atelectasis, wound infection, and septic pelvic thrombophlebitis. Septic risk factors for each condition are listed in order of the postpartum day (PPD) on which the condition generally occurs.

  • PPD 0: atelectasis risk factors include general anesthesia, cigarette smoking, and obstructive lung disease.
  • PPD 1–2: urinary tract infections risk factors include multiple catheterization during labor, multiple vaginal examinations during labor, and untreated bacteriuria.
  • PPD 2–3: endometritis ( the most common cause ) risk factors include emergency cesarean section, prolonged membrane rupture, prolonged labor, and multiple vaginal examinations during labor.
  • PPD 4–5: wound infection risk factors include emergency cesarean section, prolonged membrane rupture, prolonged labor, and multiple vaginal examination during labor.
  • PPD 5–6: septic pelvic thrombophlebitis risk factors include emergency cesarean section, prolonged membrane rupture, prolonged labor, and diffuse difficult vaginal childbirth.
  • PPD 7–21: mastitis risk factors include nipple trauma from breastfeeding.

Diagnosis

Puerperal fever is diagnosed with:

  • A temperature rise above 38 °C (100.4 °F) maintained over 24 hours or recurring during the period from the end of the first to the end of the 10th day after childbirth or abortion. (ICD-10)
  • Oral temperature of 38 °C (100.4 °F) or more on any two of the first ten days postpartum. (USJCMW)[12]

Puerperal fever (from the Latin puer, male child (boy)), is no longer favored as a diagnostic category. Instead, contemporary terminology specifies:[13]

  1. the specific target of infection: endometritis (inflammation of the inner lining of the uterus), metrophlebitis (inflammation of the veins of the uterus), and peritonitis (inflammation of the membrane lining of the abdomen).
  2. the severity of the infection: less serious infection (contained multiplication of microbes) or possibly life-threatening sepsis (uncontrolled and uncontained multiplication of microbes throughout the blood stream).

Endometritis is a polymicrobial infection. It frequently includes organisms such as Ureaplasma, Streptococcus, Mycoplasma, and Bacteroides, and may also include organisms such as Gardnerella, Chlamydia, Lactobacillus, Escherichia, and Staphylococcus.[14]

Differential diagnosis

A number of other conditions can cause fevers following delivery including: urinary tract infections, breast engorgement, atelectasis and surgical incisions, among others.[1]

Management

Antibiotics have been used to prevent and treat these infections—however, the misuse of antibiotics is a serious problem for global health.[2] It is recommended that guidelines be followed that outline when it is appropriate to give antibiotics and which antibiotics are most effective.[2]

Atelectasis: mild to moderate fever, no changes or mild rales on chest auscultation.

Management: pulmonary exercises, ambulation (deep breathing and walking).

Urinary tract infection: high fever, malaise, costovertebral tenderness, positive urine culture.

Management: antibiotics as per culture sensitivity (cephalosporine).

Endometritis: moderate fever, exquisite uterine tenderness, minimal abdominal findings.

Management: multiple agent IV antibiotics to cover polymicrobial organisms: clindamycin, gentamicin, addition of ampicillin if no response, no cultures are necessary.

Wound infection: persistent spiking fever despite antibiotics, wound erythema or fluctuance, wound drainage.

Management: antibiotics for cellulitis, open and drain wound, saline-soaked packing twice a day, secondary closure.

Septic pelvic thrombophlebitis: persistent wide fever swings despite antibiotics, usually normal abdominal or pelvic exams.

Management: IV heparin for 7–10 days at rates sufficient to prolong the PTT to double the baseline values.

Mastitis: unilateral, localized erythema, edema, tenderness.

Management: antibiotics for cellulitis, open and drain abscess if present.

Epidemiology

The number of cases of puerperal sepsis per year shows wide variations among published literature—this may be related to different definitions, recordings etc.[12] Globally, bacterial infections are the cause of 10% of maternal deaths—this is more common in low income countries but is also a direct cause of maternal deaths in high income countries.[2][15]

In the United States, puerperal infections are believed to occur in between one and eight percent of all births. About three die from puerperal sepsis for every 100,000 births. The single most important risk factor is Caesarean section.[16] The number of maternal deaths in the United States is about 13 in 100,000. They make up about 11% of pregnancy related deaths in the United States.[1]

In the United Kingdom from 1985–2005, the number of direct deaths associated with genital tract sepsis per 100,000 pregnancies was 0.40–0.85.[17] In 2003–2005, genital tract sepsis accounted for 14% of direct causes of maternal death.[18]

Puerperal infections in the 18th and 19th centuries affected, on average, 6 to 9 women in every 1,000 births, killing two to three of them with peritonitis or sepsis. It was the single most common cause of maternal mortality, accounting for about half of all deaths related to childbirth, and was second only to tuberculosis in killing women of childbearing age. A rough estimate is that about 250,000–500,000 died from puerperal fever in the 18th and 19th centuries in England and Wales alone.[19]

History

Although it had been recognized from as early as the time of the Hippocratic corpus that women in childbed were prone to fevers, the distinct name, "puerperal fever" appears in historical records only from the early 18th century.[20]

The death rate for women giving birth decreased in the 20th century in developed countries. The decline may be partly attributed to improved environmental conditions, better obstetrical care, and the use of antibiotics. Another reason appears to be a lessening of the virulence or invasiveness of Streptococcus pyogenes. This organism is also the cause of scarlet fever, which over the same period has also declined markedly in severity and incidence.

"The Doctor's Plague"
In his 1861 book, Ignaz Semmelweis presented evidence to demonstrate that the advent of pathological anatomy in Vienna in 1823 (vertical line) was correlated to the incidence of fatal childbed fever there. Onset of chlorine handwash in 1847 marked by vertical line. Rates for Dublin maternity hospital, which had no pathological anatomy, is shown for comparison (view rates). His efforts were futile, however.

From the 1600s through the mid-to-late 1800s, the majority of childbed fever cases were caused by the doctors themselves. With no knowledge of germs, doctors did not believe hand washing was needed.

Hospitals for childbirth became common in the 17th century in many European cities. These "lying-in" hospitals were established at a time when there was no knowledge of antisepsis or epidemiology, and women were subjected to crowding, frequent vaginal examinations, and the use of contaminated instruments, dressings, and bedding. It was common for a doctor to deliver one baby after another, without washing his hands or changing clothes between patients.

The first recorded epidemic of puerperal fever occurred at the Hôtel-Dieu de Paris in 1646. Hospitals throughout Europe and America consistently reported death rates between 20% to 25% of all women giving birth, punctuated by intermittent epidemics with up to 100% fatalities of women giving birth in childbirth wards.[21]

In the 1800s Ignaz Semmelweis noticed that women giving birth at home had a much lower incidence of childbed fever than those giving birth in the doctor's maternity ward. His investigation discovered that washing hands with an antiseptic, in this case a calcium chloride solution, before a delivery reduced childbed fever fatalities by 90%.[22] Publication of his findings was not well received by the medical profession. The idea conflicted both with the existing medical concepts and with the image doctors had of themselves.[23] The scorn and ridicule of doctors was so extreme that Semmelweis moved from Vienna and, after suffering a breakdown, was eventually committed to a mental asylum where he died.[24]

Semmelweis was not the only doctor ignored after sounding a warning about this issue: in Treatise on the Epidemic of Puerperal Fever (1795), ex-naval surgeon and Aberdonian obstetrician Alexander Gordon (1752–1799) warned that the disease was transmitted from one case to another by midwives and doctors. Gordon wrote, "It is a disagreeable declaration for me to mention, that I myself was the means of carrying the infection to a great number of women."[25][26]

Thomas Watson (1792–1882), Professor of Medicine at King's College Hospital, London, wrote in 1842: "Wherever puerperal fever is rife, or when a practitioner has attended any one instance of it, he should use most diligent ablution." Watson recommended handwashing with chlorine solution and changes of clothing for obstetric attendants "to prevent the practitioner becoming a vehicle of contagion and death between one patient and another."[27][28]

Hygienic measures
Ignaz Semmelweis, discoverer of some of the causes of puerperal fever

In 1843, Oliver Wendell Holmes Sr. published The Contagiousness of Puerperal Fever and controversially concluded that puerperal fever was frequently carried from patient to patient by physicians and nurses; he suggested that clean clothing and avoidance of autopsies by those aiding birth would prevent the spread of puerperal fever.[29][30] Holmes quoted Dr. James Blundell as stating, "... in my own family, I had rather that those I esteemed the most should be delivered unaided, in a stable, by the mangerside, than that they should receive the best help, in the fairest apartment, but exposed to the vapors of this pitiless disease."[31]

Holmes' conclusions were ridiculed by many contemporaries, including Charles Delucena Meigs, a well-known obstetrician, who stated, "Doctors are gentlemen, and gentlemen's hands are clean."[32] Richard Gordon states that Holmes' exhortations "outraged obstetricians, particularly in Philadelphia".[33] In those days, "surgeons operated in blood-stiffened frock coats—the stiffer the coat, the prouder the busy surgeon", "pus was as inseparable from surgery as blood", and "Cleanliness was next to prudishness". He quotes Sir Frederick Treves on that era: "There was no object in being clean. Indeed, cleanliness was out of place. It was considered to be finicking and affected. An executioner might as well manicure his nails before chopping off a head".[34][35]

In 1844, Ignaz Semmelweis was appointed assistant lecturer in the First Obstetric Division of the Vienna General Hospital (Allgemeines Krankenhaus), where medical students received their training. Working without knowledge of Holmes' essay, Semmelweis noticed his ward's 16% mortality rate from fever was substantially higher than the 2% mortality rate in the Second Division, where midwifery students were trained. Semmelweis also noticed that puerperal fever was rare in women who gave birth before arriving at the hospital. Semmelweis noted that doctors in First Division performed autopsies each morning on women who had died the previous day, but the midwives were not required or allowed to perform such autopsies. He made the connection between the autopsies and puerperal fever after a colleague, Jakob Kolletschka, died of sepsis after accidentally cutting his hand while performing an autopsy.

Semmelweis began experimenting with various cleansing agents and, from May 1847, ordered all doctors and students working in the First Division wash their hands in chlorinated lime solution before starting ward work, and later before each vaginal examination. The mortality rate from puerperal fever in the division fell from 18% in May 1847 to less than 3% in June–November of the same year.[36] While his results were extraordinary, he was treated with skepticism and ridicule (see Response to Semmelweis).

He did the same work in St. Rochus hospital in Pest, Hungary, and published his findings in 1860, but his discovery was again ignored.[37]

In 1935, Leonard Colebrook showed Prontosil was effective against haemolytic streptococcus and hence a cure for puerperal fever.[38][39]

Notable cases
See also: List of women who died in childbirth

Elite status was no protection against postpartum infections, as the deaths of several English queens attest. Elizabeth of York, queen consort of Henry VII, died of puerperal fever one week after giving birth to a daughter, who also died. Her son Henry VIII had two wives who died this way, Jane Seymour and Catherine Parr.

Suzanne Barnard, mother of philosopher Jean-Jacques Rousseau, contracted childbed fever after giving birth to him, and died nine days later. Her infant son was also in perilous health following the birth; the adult Rousseau later wrote that "I came into the world with so few signs of life that little hope was entertained of preserving me". He was nursed back to health by an aunt.[40] French natural philosopher Émilie du Châtelet died in 1749. Mary Wollstonecraft, author of Vindication of the Rights of Woman, died ten days after giving birth to her second daughter, who grew up to write Frankenstein. Other notable victims include African-American poet Phillis Wheatley (1784), British housekeeping authority Isabella Beeton, and American author Jean Webster in 1916 died of puerperal fever.

In Charles Dickens' novel A Christmas Carol, it is implied that both Scrooge's mother and younger sister perished from this condition, explaining the character's animosity towards his nephew Fred and also his poor relationship with his own father.

See also

References
  1. "37". Williams Obstetrics (24th ed.). McGraw-Hill Professional. 2014. pp. Chapter 37. ISBN 978-0-07-179893-8.
  2. WHO recommendations for prevention and treatment of maternal peripartum infections (PDF). World Health Organization. 2015. p. 1. ISBN 978-9241549363. PMID 26598777. Archived (PDF) from the original on 2016-02-07.
  3. GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
  4. GBD 2015 Mortality and Causes of Death, Collaborators. (8 October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281.
  5. Hiralal Konar (2014). DC Dutta's Textbook of Obstetrics. JP Medical Ltd. p. 432. ISBN 978-93-5152-067-2. Archived from the original on 2015-12-08.
  6. "Cover of Hacker & Moore's Essentials of Obstetrics and Gynecology". Hacker & Moore's essentials of obstetrics and gynecology (6 ed.). Elsevier Canada. 2015. pp. 276–290. ISBN 978-1455775583.
  7. GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–171. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442.
  8. Walvekar, Vandana (2005). Manual of perinatal infections. New Delhi: Jaypee Bros. p. 153. ISBN 978-81-8061-472-9. Archived from the original on 2016-03-04.
  9. Magner, Lois N. (1992). A history of medicine. New York: Dekker. pp. 257–258. ISBN 978-0-8247-8673-1.
  10. Anderson, BL (April 2014). "Puerperal group A streptococcal infection: beyond Semmelweis". Obstetrics and Gynecology. 123 (4): 874–882. doi:10.1097/aog.0000000000000175. PMID 24785617.
  11. Ataman, AD; Vatanoğlu-Lutz, EE; Yıldırım, G (2013). "Medicine in stamps-Ignaz Semmelweis and Puerperal Fever". Journal of the Turkish German Gynecological Association. 14 (1): 35–9. doi:10.5152/jtgga.2013.08. PMC 3881728. PMID 24592068.
  12. The Global Incidence of Puerperal Sepsis Protocol for a Systematic Review Archived 2008-12-17 at the Wayback Machine
  13. Carter (2005):98
  14. Berenson, AB (April 1990). "Bacteriologic Findings of Post-Cesarian Endometritis in Adolescents". Obstetrics and Gynecology. 75 (4): 627–629. PMID 2314783. Archived from the original on 2013-11-03.
  15. "WHO recommendations for prevention and treatment of maternal peripartum infections" (PDF). Archived (PDF) from the original on 2016-03-06.
  16. Carter, K. Codell; Carter, Barbara R. (2005). Childbed fever. A scientific biography of Ignaz Semmelweis. Transaction Publishers. p. 100. ISBN 978-1-4128-0467-7.
  17. Lewis, Gwyneth, ed. (2007). Saving Mothers' Lives: Reviewing maternal deaths to make motherhood safer – 2003–2005. The Seventh Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. CEMACH. p. 97. ISBN 978-0-9533536-8-2.
  18. CEMACH: Saving Mothers' Lives 2003–2005 Archived 2008-05-21 at the Wayback Machine
  19. Loudon, Irvine (9 March 2000). The Tragedy of Childbed Fever (PDF). Oxford University Press, USA. p. 6. ISBN 978-0-19-820499-2. Archived from the original (PDF) on 11 February 2012.
  20. The debate about when this term first emerged is presented by Irvine Loudon, The tragedy of childbed fever, Oxford University Press, 2000, p. 8.
  21. Loudon I. "Deaths in childbed from the eighteenth century to 1935". Med History 1986; 30: 1–41
  22. Caplan, Caralee E. (1995). "The Childbed Fever Mystery and the Meaning of Medical Journalism". McGill Journal of Medicine. 1 (1). Archived from the original on 2012-07-07.
  23. Wyklicky H, Skopec M (1983). "Ignaz Philipp Semmelweis, the prophet of bacteriology". Infect Control. 4 (5): 367–370. doi:10.1017/S0195941700059762. PMID 6354955.
  24. De Costa, Caroline M (Nov 2002). ""The contagiousness of childbed fever": a short history of puerperal sepsis and its treatment". The Medical Journal of Australia. 177 (11–12): 668–671. doi:10.5694/j.1326-5377.2002.tb05004.x. PMID 12463995. S2CID 12164328. Archived from the original on 2006-12-03.
  25. Gordon, Alexander (1795). A Treatise on the Epidemic Puerperal Fever of Aberdeen. London, England: G.G. and J. Robinson. pp. 63–64. On p. 63, Gordon recognized the puerperal fever as infectious: "But this disease seized such women only, as were visited, or delivered, by a practitioner, or taken care of by a nurse, who had previously attended patients affected with the disease. In short, I had evident proofs of its infectious nature, and that the infection was as readily communicated as that of the smallpox, or measles, and operated more speedily than any other infection, with which I am acquainted." From p. 64: "It is a disagreeable declaration for me to mention, that I myself was the means of carrying the infection to a great number of women."
  26. "Treatise on the Epidemic of Puerperal Fever". www.general-anaesthesia.com. Archived from the original on July 20, 2008. Retrieved September 15, 2011.
  27. Watson (February 18, 1842). "Lectures on the principles and practice of physic: Diseases of the abdomen". The London Medical Gazette. 29: 801–808. From p. 806: "Whenever puerperal fever is rife, or when a practitioner has attended any one example of it, he should use most diligent ablution; he should even wash his hands with some disinfecting fluid, a weak solution of chlorine for instance: he should avoid going in the same dress to any other of his midwifery patients: in short, he should take all those precautions which, when the danger is understood, common sense will suggest, against his clothes or his body becoming a vehicle of contagion and death between one patient and another."
  28. The Medical Journal of Australia."The contagiousness of childbed fever: a short history of puerperal sepsis and its treatment" Archived 2006-12-03 at the Wayback Machine
  29. Holmes, Oliver W. (1842–1843). "On the contagiousness of puerperal fever". The New England Quarterly Journal of Medicine. 1: 503–530.
  30. Oliver Wendell Holmes: The Contagiousness of Puerperal Fever Archived 2007-02-03 at the Wayback Machine
  31. (Holmes, 1842–1843), p. 510.
  32. Meigs, Charles Delucena (1854). On the Nature, Signs, and Treatment of Childbed Fevers: In a Series of Letters Addressed to the Students of His Class. Philadelphia, Pennsylvania: Blanchard and Lea. p. 104. From p. 104: Speaking of a physician in Philadelphia, Pennsylvania, Meigs said: "He is a gentlemen who is scrupulously careful of his personal appearance, … But a gentleman's hands are clean."
  33. Gordon, Richard (1983). "Disastrous Motherhood: Tales from the Vienna Wards". Great Medical Disasters. London: Hutchinson & Co. pp. 43–46 [43].
  34. Treves, Frederick (1923). "Ch. 2: The Old Receiving Room". The Elephant Man and Other Reminiscences. London, England: Cassell and Company, Ltd. pp. 56–57.
  35. Gordon, Richard (1983) p. 44
  36. Raju, T. N. (1999). "Ignác Semmelweis and the etiology of fetal and neonatal sepsis". Journal of Perinatology. 19 (4): 307–310. doi:10.1038/sj.jp.7200155. PMID 10685244.
  37. Christa Colyer."Childbed fever: a nineteenth-century mystery," Archived 2009-04-16 at the Wayback Machine National Center for Case Study Teaching in Science, December 8, 1999 (revised October 27, 2003).
  38. Colebrook, L; Kenny, M (June 6, 1936). "Treatment of Human Puerperal Infections, and of Experimental Infections in Mice, with Prontosil".Lancet 227(1): 1279–1286.
  39. Sue Bale; Vanessa Jones (2006). Wound care nursing. Elsevier Health Sciences. p. 54. ISBN 978-0-7234-3344-6. Retrieved 2009-08-05.
  40. Quoted from Will Durant's "The Age of Rousseau".

Further reading
  • Chaim W, Burstein E (August 2003). "Postpartum infection treatments: a review". Expert Opinion on Pharmacotherapy (review). 4 (8): 1297–313. doi:10.1517/14656566.4.8.1297. PMID 12877638. S2CID 26781321.
  • French L (August 2003). "Prevention and treatment of postpartum endometritis". Current Women's Health Reports (review). 3 (4): 274–9. PMID 12844449.
  • Calhoun BC, Brost B (June 1995). "Emergency management of sudden puerperal fever". Obstetrics and Gynecology Clinics of North America (review). 22 (2): 357–67. PMID 7651676.
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