Phosphatidylinositol 3-phosphate

Phosphatidylinositol 3-phosphate
Names
	Other names sn-1-stearoyl-2-arachidonoyl phosphatidylinositol 3-phosphate
Identifiers
Abbreviations	PtdIns3P ; PtdIns(3)P ; PI3P ; PI(3)P
PubChem CID	6857403;
Properties
Chemical formula	C11H20O16P2
Molar mass	470.214 g/mol, neutral with fatty acid composition - 18:0, 20:4
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Phosphatidylinositol 3-phosphate (PtdIns3P) is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes. It is the product of both the class II and III phosphoinositide 3-kinases (PI 3-kinases) activity on phosphatidylinositol.[1]

PtdIns3P is dephosphorylated by the myotubularin family of phosphatases, on the D3 position of the inositol ring, and can be converted to PtdIns(3,5)P₂ by the lipid kinase PIKfyve.[2]

Both FYVE domains and PX domains – found in proteins such as SNX1, HGS, and EEA1 – bind to PtdIns3P.[3]

The majority of PtdIns3P appears to be constitutively synthesised by the class III PI 3-kinase, PIK3C3 (Vps34), at endocytic membranes. Class II PI 3-kinases also appear to synthesise PtdIns3P, their activity however appears to be regulated by a range of stimuli, including growth factors. This suggests that specific pools of PtdIns3P may be synthesised upon cell stimulation.

References

Gillooly DJ, Simonsen A, Stenmark H (April 2001). "Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins". The Biochemical Journal. 355 (Pt 2): 249–58. doi:10.1042/0264-6021:3550249. PMC 1221734. PMID 11284710.
De Craene JO, Bertazzi DL, Bär S, Friant S (March 2017). "Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways". International Journal of Molecular Sciences. 18 (3): 634. doi:10.3390/ijms18030634. PMC 5372647. PMID 28294977.
Stenmark H, Aasland R, Driscoll PC (February 2002). "The phosphatidylinositol 3-phosphate-binding FYVE finger". FEBS Letters. 513 (1): 77–84. doi:10.1016/s0014-5793(01)03308-7. PMID 11911884.

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[1] Gillooly DJ, Simonsen A, Stenmark H (April 2001). "Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins". The Biochemical Journal. 355 (Pt 2): 249–58. doi:10.1042/0264-6021:3550249. PMC 1221734. PMID 11284710.

[2] De Craene JO, Bertazzi DL, Bär S, Friant S (March 2017). "Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways". International Journal of Molecular Sciences. 18 (3): 634. doi:10.3390/ijms18030634. PMC 5372647. PMID 28294977.

[3] Stenmark H, Aasland R, Driscoll PC (February 2002). "The phosphatidylinositol 3-phosphate-binding FYVE finger". FEBS Letters. 513 (1): 77–84. doi:10.1016/s0014-5793(01)03308-7. PMID 11911884.