PIK3C3

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene.[5][6] It's a class III phosphoinositide 3-kinase.

PIK3C3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWL, 5ANL
Identifiers
Aliases	PIK3C3, VPS34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3
External IDs	OMIM: 602609 MGI: 2445019 HomoloGene: 1986 GeneCards: PIK3C3
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.3 Start 41,955,234 bp[1] End 42,087,830 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 30,272,747 bp[2] End 30,348,126 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • 1-phosphatidylinositol-3-kinase activity • GO:0001948 protein binding • phosphatidylinositol 3-kinase activity • ATP binding • kinase activity Cellular component • cytosol • endosome • late endosome • phagocytic vesicle membrane • membrane • phosphatidylinositol 3-kinase complex, class III • autophagosome • midbody • phagocytic vesicle • GO:0035085 axoneme • cytoplasmic vesicle • autolysosome • pre-autophagosomal structure • peroxisome • phosphatidylinositol 3-kinase complex, class III, type I • phosphatidylinositol 3-kinase complex, class III, type II • cytoplasm • intracellular Biological process • cellular response to glucose starvation • regulation of cytokinesis • phosphorylation • protein processing • response to leucine • cytokinesis • endosome organization • cell division • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • early endosome to late endosome transport • phosphatidylinositol biosynthetic process • cell cycle • toll-like receptor 9 signaling pathway • macroautophagy • regulation of protein secretion • protein localization to pre-autophagosomal structure • cellular response to starvation • protein lipidation • autophagy • autophagosome assembly • protein phosphorylation • endocytosis • autophagy of peroxisome • phosphatidylinositol-mediated signaling • interleukin-7-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5289	225326
Ensembl	ENSG00000078142	ENSMUSG00000033628
UniProt	Q8NEB9	Q6PF93
RefSeq (mRNA)	NM_001308020 NM_002647	NM_181414
RefSeq (protein)	NP_001294949 NP_002638	NP_852079
Location (UCSC)	Chr 18: 41.96 – 42.09 Mb	Chr 18: 30.27 – 30.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000078142 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033628 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system". EMBO J. 14 (14): 3339–48. doi:10.1002/j.1460-2075.1995.tb07340.x. PMC 394401. PMID 7628435.
6. "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3".

Further reading

• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231. S2CID 11362623.
• Vogel LB, Fujita DJ (1994). "The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes". Mol. Cell. Biol. 13 (12): 7408–17. doi:10.1128/mcb.13.12.7408. PMC 364812. PMID 7504174.
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Panaretou C, Domin J, Cockcroft S, Waterfield MD (1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793.
• Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID 9394803.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID 9446795.
• Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells". AIDS. 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406. S2CID 25758704.
• Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity". Eur. J. Immunol. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes". Blood. 97 (2): 352–8. doi:10.1182/blood.V97.2.352. PMID 11154208.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
• Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.
• Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism". J. Immunol. 169 (1): 254–60. doi:10.4049/jimmunol.169.1.254. PMID 12077252.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages". J. Virol. 77 (4): 2539–49. doi:10.1128/JVI.77.4.2539-2549.2003. PMC 141101. PMID 12551992.
• Vergne I, Chua J, Deretic V (2003). "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade". J. Exp. Med. 198 (4): 653–9. doi:10.1084/jem.20030527. PMC 2194170. PMID 12925680.
• Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells". J. Neurovirol. 9 (6): 584–93. doi:10.1080/jnv.9.6.584.593. PMID 14602571.