Olokizumab
Olokizumab is an immunomodulator. It binds to interleukin 6.[1] Hence acting as an Anti-IL-6 therapeutic aimed at inflammatory disease e.g. rheumatoid arthritis (RA).
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized |
| Target | IL6 |
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It had promising results in a phase II trial against placebo or tocilizumab for patients with moderate to severe whan.[2][3]
Olokizumab was approved for medical use in Russia. On May 21, 2020, the Russian Health Ministry approved brand name Artlegia (olokizumab).
Olokizumab (64 mg once) is used as emergence experimental cytokine storm COVID-19 complications treatment.[4]
References
- World Health Organization (2010). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 103" (PDF). WHO Drug Information.
- Walsh N (6 August 2014). "RheumShorts: IL-6 and RA, Life and Death, Surgery in Lupus".
- Genovese MC, Fleischmann R, Furst D, Janssen N, Carter J, Dasgupta B, et al. (September 2014). "Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study". Annals of the Rheumatic Diseases. 73 (9): 1607–15. doi:10.1136/annrheumdis-2013-204760. PMC 4145439. PMID 24641941.
- https://www.reuters.com/article/us-health-coronavirus-russia-drug-idUSKBN26T2AN
External links
- "Artlegia". Russian drug reference. Medum.ru.
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