IL18BP

Interleukin-18-binding protein is a protein that in humans is encoded by the IL18BP gene.[5][6]

IL18BP
Identifiers
Aliases	IL18BP, IL18BPa, interleukin 18 binding protein, FVH
External IDs	OMIM: 604113 MGI: 1333800 HomoloGene: 7781 GeneCards: IL18BP
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 71,998,613 bp[1] End 72,005,715 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 102,014,885 bp[2] End 102,018,690 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor antagonist activity • interleukin-18 binding Cellular component • extracellular region • extracellular exosome • extracellular Biological process • T-helper 1 type immune response • cellular response to tumor necrosis factor • response to lipopolysaccharide • cellular response to hydrogen peroxide • extracellular negative regulation of signal transduction • interleukin-18-mediated signaling pathway • cellular response to cytokine stimulus • negative regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10068	16068
Ensembl	ENSG00000137496	ENSMUSG00000070427
UniProt	O95998	Q9Z0M9
RefSeq (mRNA)	NM_001039659 NM_001039660 NM_001145055 NM_001145057 NM_005699 NM_173042 NM_173043 NM_173044	NM_010531 NM_001363982 NM_001382458
RefSeq (protein)	NP_001034748 NP_001034749 NP_001138527 NP_001138529 NP_005690 NP_766630 NP_766632 NP_766632.2	NP_034661 NP_001350911 NP_001369387
Location (UCSC)	Chr 11: 72 – 72.01 Mb	Chr 7: 102.01 – 102.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000137496 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070427 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (Mar 1999). "Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response". Immunity. 10 (1): 127–36. doi:10.1016/S1074-7613(00)80013-8. PMID 10023777.
6. "Entrez Gene: IL18BP interleukin 18 binding protein".

Further reading

• Dinarello CA (2002). "Novel targets for interleukin 18 binding protein". Ann. Rheum. Dis. 60 Suppl 3 (Suppl 3): iii18–24. doi:10.1136/ard.60.90003.iii18 (inactive 2021-01-14). PMC 1766679. PMID 11890646.CS1 maint: DOI inactive as of January 2021 (link)
• Loughney K, Martins TJ, Harris EA, et al. (1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J. Biol. Chem. 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.
• Aizawa Y, Akita K, Taniai M, et al. (1999). "Cloning and expression of interleukin-18 binding protein". FEBS Lett. 445 (2–3): 338–42. doi:10.1016/S0014-5793(99)00148-9. PMID 10094485. S2CID 21572907.
• Xiang Y, Moss B (1999). "Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus". Virology. 257 (2): 297–302. doi:10.1006/viro.1999.9676. PMID 10329540.
• Kim SH, Eisenstein M, Reznikov L, et al. (2000). "Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1190–5. Bibcode:2000PNAS...97.1190K. doi:10.1073/pnas.97.3.1190. PMC 15564. PMID 10655506.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Michibata H, Yanaka N, Kanoh Y, et al. (2001). "Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization". Biochim. Biophys. Acta. 1517 (2): 278–87. doi:10.1016/s0167-4781(00)00293-1. PMID 11342109.
• Paulukat J, Bosmann M, Nold M, et al. (2001). "Expression and release of IL-18 binding protein in response to IFN-gamma". J. Immunol. 167 (12): 7038–43. doi:10.4049/jimmunol.167.12.7038. PMID 11739524.
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
• Corbaz A, ten Hove T, Herren S, et al. (2002). "IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease". J. Immunol. 168 (7): 3608–16. doi:10.4049/jimmunol.168.7.3608. PMID 11907126.
• Bufler P, Azam T, Gamboni-Robertson F, et al. (2002). "A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13723–8. Bibcode:2002PNAS...9913723B. doi:10.1073/pnas.212519099. PMC 129755. PMID 12381835.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hurgin V, Novick D, Rubinstein M (2003). "The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16957–62. doi:10.1073/pnas.262663399. PMC 139251. PMID 12482935.
• Plitz T, Saint-Mézard P, Satho M, et al. (2003). "IL-18 binding protein protects against contact hypersensitivity". J. Immunol. 171 (3): 1164–71. doi:10.4049/jimmunol.171.3.1164. PMID 12874202.
• Fantuzzi G, Banda NK, Guthridge C, et al. (2004). "Generation and characterization of mice transgenic for human IL-18-binding protein isoform a". J. Leukoc. Biol. 74 (5): 889–96. doi:10.1189/jlb.0503230. PMID 12960225. S2CID 23024026.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kawashima M, Novick D, Rubinstein M, Miossec P (2004). "Regulation of interleukin-18 binding protein production by blood and synovial cells from patients with rheumatoid arthritis". Arthritis Rheum. 50 (6): 1800–5. doi:10.1002/art.20320. PMID 15188356.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.

External links

• IL18BP human gene location in the UCSC Genome Browser.
• IL18BP human gene details in the UCSC Genome Browser.