Neuregulin 2

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.[5][6][7]

NRG2
Identifiers
Aliases	NRG2, DON1, HRG2, NTAK, neuregulin 2
External IDs	OMIM: 603818 MGI: 1098246 HomoloGene: 75024 GeneCards: NRG2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.2 Start 139,846,779 bp[1] End 140,043,299 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B2|18 19.38 cM Start 36,017,652 bp[2] End 36,197,380 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • growth factor activity • receptor binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • integral component of membrane • membrane • cell membrane • extracellular region • intracellular • extracellular Biological process • MAPK cascade • signal transduction • regulation of cell motility • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • ERBB2 signaling pathway • GO:0007243 intracellular signal transduction • animal organ development • regulation of receptor activity • positive regulation of protein kinase B signaling • nervous system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9542	100042150
Ensembl	ENSG00000158458	ENSMUSG00000060275
UniProt	O14511	P56974
RefSeq (mRNA)	NM_001184935 NM_004883 NM_013981 NM_013982 NM_013983 NM_013984 NM_013985	NM_001167891 NM_001382420
RefSeq (protein)	NP_001171864 NP_004874 NP_053584 NP_053585 NP_053586	n/a
Location (UCSC)	Chr 5: 139.85 – 140.04 Mb	Chr 18: 36.02 – 36.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000158458 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060275 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NRG2 neuregulin 2".
6. Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114. S2CID 4359654.
7. Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115. S2CID 4310136.

Further reading

• Chang H, Riese DJ, Gilbert W, et al. (1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114. S2CID 4359654.
• Carraway KL, Weber JL, Unger MJ, et al. (1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature. 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115. S2CID 4310136.
• Busfield SJ, Michnick DA, Chickering TW, et al. (1997). "Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus". Mol. Cell. Biol. 17 (7): 4007–14. doi:10.1128/MCB.17.7.4007. PMC 232253. PMID 9199335.
• Higashiyama S, Horikawa M, Yamada K, et al. (1998). "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4". J. Biochem. 122 (3): 675–80. doi:10.1093/oxfordjournals.jbchem.a021806. PMID 9348101.
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
• Ring HZ, Chang H, Guilbot A, et al. (1999). "The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q". Hum. Genet. 104 (4): 326–32. doi:10.1007/s004390050961. PMID 10369162. S2CID 8684113.
• Yamada K, Ichino N, Nishii K, et al. (2000). "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA". Gene. 255 (1): 15–24. doi:10.1016/S0378-1119(00)00309-7. PMID 10974560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nakano N, Higashiyama S, Ohmoto H, et al. (2004). "The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis". J. Biol. Chem. 279 (12): 11465–70. doi:10.1074/jbc.M311045200. PMID 14722120.
• Ponomareva ON, Ma H, Dakour R, et al. (2005). "Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing". Neuroscience. 134 (2): 495–503. doi:10.1016/j.neuroscience.2005.04.028. PMID 15961242. S2CID 37483720.
• Fan BJ, Ko WC, Wang DY, et al. (2007). "Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene". Mol. Vis. 13: 779–84. PMC 2768763. PMID 17563728.