Monongahela virus

Monongahela virus (MGLV) is a single-stranded, negative-sense Orthohantavirus virus of zoonotic origin that causes Hantavirus pulmonary syndrome.[1]

Monongahela virus
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Species: Sin Nombre orthohantavirus
Virus:
Monongahela virus

Discovery of virus

Monongahela virus was first detected in Peromyscus maniculatus nubiterrae (Cloudland deer mice) captured in the Monongahela National Forest in West Virginia in 1985.[2]

Transmission

This member virus of Sin Nombre orthohantavirus has not been shown to transfer from person to person. Transmission by aerosolized rodent excreta still remains the only known way the virus is transmitted to humans. In general, droplet and/or fomite transfer has not been shown in the hantaviruses in either the hemorrhagic or pulmonary forms.[3][4]

In two cases in Pennsylvania, the patients were living in rural areas and had recent exposure to rodent excreta prior to the onset of symptoms. Both patients developed rapid onset of respiratory distress and pulmonary edema, believed to be the result of cytokine storm, and both expired within 5 days of onset of symptoms.

See also

References
  1. Luther V. Rhodes, Cinnia Huang, Angela J. Sanchez, Stuart T. Nichol§, Sherif R. Zaki§, Thomas G. Ksiazek, J.G. Humphreys¶, James J. Freeman*, and Kenneth R. Knecht. Hantavirus Pulmonary Syndrome Associated with Monongahela Virus, Pennsylvania. Research. Volume 6, Number 6—December 2000.
  2. Song JW, Baek LJ, Nagle JW, Schlitter D, Yanagihara R (1996). "Genetic and phylogenetic analysis of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States". Arch Virol. 141 (5): 959–67. doi:10.1007/bf01718170. PMID 8678841.
  3. Peters, C.J. (2006). "Emerging Infections: Lessons from the Viral Hemorrhagic Fevers". Transactions of the American Clinical and Climatological Association. 117: 189–197. PMC 1500910. PMID 18528473.
  4. Crowley, J.; Crusberg, T. "Ebola and Marburg Virus Genomic Structure, Comparative and Molecular Biology". Dept. of Biology & Biotechnology, Worcester Polytechnic Institute. Archived from the original on 2013-10-15.
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