MST1

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1) gene.[5][6][7]

MST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ASU, 4QT8
Identifiers
Aliases	MST1, D3F15S2, DNF15S2, HGFL, MSP, NF15S2, macrophage stimulating 1
External IDs	OMIM: 142408 MGI: 96080 HomoloGene: 7360 GeneCards: MST1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 49,683,947 bp[1] End 49,689,501 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 59.07 cM Start 108,080,436 bp[2] End 108,085,003 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor tyrosine kinase binding • GO:0001948 protein binding • serine-type endopeptidase activity Cellular component • extracellular region • extracellular • collagen-containing extracellular matrix Biological process • proteolysis • regulation of cAMP-dependent protein kinase activity • hepatocyte growth factor receptor signaling pathway • negative regulation of gluconeogenesis • regulation of macrophage chemotaxis • positive regulation of mammary gland epithelial cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4485	15235
Ensembl	ENSG00000173531	ENSMUSG00000032591
UniProt	P26927	P26928
RefSeq (mRNA)	NM_020998	NM_008243
RefSeq (protein)	NP_066278	NP_032269
Location (UCSC)	Chr 3: 49.68 – 49.69 Mb	Chr 9: 108.08 – 108.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000173531 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032591 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (Oct 1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel". Am J Hum Genet. 43 (4): 442–51. PMC 1715492. PMID 2902784.
6. Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ (Aug 1993). "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3". J Biol Chem. 268 (21): 15461–8. PMID 8393443.
7. "Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)".

Further reading

• Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40): 9768–80. doi:10.1021/bi00104a029. PMID 1655021.
• Skeel A, Yoshimura T, Showalter SD, et al. (1991). "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity". J. Exp. Med. 173 (5): 1227–34. doi:10.1084/jem.173.5.1227. PMC 2118857. PMID 1827141.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein". J. Biol. Chem. 271 (15): 9024–32. doi:10.1074/jbc.271.15.9024. PMID 8621550.
• Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain". J. Biol. Chem. 271 (35): 21049–53. doi:10.1074/jbc.271.35.21049. PMID 8702870.
• Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. doi:10.1172/JCI119214. PMC 507853. PMID 9045873.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yoshikawa W, Hara H, Takehara T, et al. (1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein". Arch. Biochem. Biophys. 363 (2): 356–60. doi:10.1006/abbi.1998.1090. PMID 10068459.
• Degen SJ, McDowell SA, Waltz SE, et al. (2000). "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein". DNA Seq. 8 (6): 409–13. doi:10.3109/10425179809020903. PMID 10728827.
• Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein". J. Biol. Chem. 276 (24): 21932–7. doi:10.1074/jbc.M100652200. PMID 11274154.
• Rampino T, Collesi C, Gregorini M, et al. (2002). "Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells". J. Am. Soc. Nephrol. 13 (3): 649–57. PMID 11856768.
• Zhou YQ, Chen YQ, Fisher JH, Wang MH (2002). "Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages". J. Biol. Chem. 277 (41): 38104–10. doi:10.1074/jbc.M206167200. PMID 12177064.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell. 5 (2): 257–71. doi:10.1016/S1534-5807(03)00201-6. PMID 12919677.
• Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
• Matsuzaki S, Canis M, Pouly JL, et al. (2005). "The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis". Mol. Hum. Reprod. 11 (5): 345–9. doi:10.1093/molehr/gah162. PMID 15764806.
• Zalcenstein A, Weisz L, Stambolsky P, et al. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53". Oncogene. 25 (3): 359–69. doi:10.1038/sj.onc.1209061. PMID 16170349.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.