L-687,384

L-687,384 is a sigma receptor agonist, selective for the σ₁ subtype,[1] as well as an NMDA antagonist.[2]

L-687,384

Clinical data
ATC code	none
Identifiers
IUPAC name 1'-benzylspiro[2,3-dihydro-1H-naphthalene-4,4'-piperidine]
CAS Number	95417-67-7
PubChem CID	125328
ChemSpider	111534
UNII	NVE9K68QA3
CompTox Dashboard (EPA)	DTXSID30241828
Chemical and physical data
Formula	C21H25N
Molar mass	291.438 g·mol^−1
3D model (JSmol)	Interactive image
SMILES c3ccccc3CN2CCC1(CC2)CCCc4c1cccc4
InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2 Key:MLDCBJPLHBPJET-UHFFFAOYSA-N
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References

1. Bergeron R, Debonnel G (February 1997). "Effects of low and high doses of selective sigma ligands: further evidence suggesting the existence of different subtypes of sigma receptors". Psychopharmacology. 129 (3): 215–24. doi:10.1007/s002130050183. PMID 9084059.
2. McLarnon J, Sawyer D, Church J (June 1994). "The actions of L-687,384, a sigma receptor ligand, on NMDA-induced currents in cultured rat hippocampal pyramidal neurons". Neuroscience Letters. 174 (2): 181–4. doi:10.1016/0304-3940(94)90016-7. PMID 7526288.