Glycyrrhizinate beta-glucuronidase
In enzymology, a glycyrrhizinate beta-glucuronidase (EC 3.2.1.128) is an enzyme that catalyzes the chemical reaction
- glycyrrhizinate + H2O 1,2-beta-D-glucuronosyl-D-glucuronate + glycyrrhetinate
| glycyrrhizinate beta-glucuronidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.128 | ||||||||
| CAS number | 102484-56-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are glycyrrhizinate and H2O, whereas its two products are 1,2-beta-D-glucuronosyl-D-glucuronate and glycyrrhetinate.
This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycyrrhizinate glucuronosylhydrolase. Other names in common use include glycyrrhizin beta-hydrolase, glycyrrhizin hydrolase, and glycyrrhizinic acid hydrolase.
References
- Muro, T, Kuramoto T, Imoto K, Okada S (1986). "Purification and some properties of glycyrrhizinic acid hydrolase from Aspergillus niger GRM3". Agric. Biol. Chem. 50 (3): 687–692. doi:10.1271/bbb1961.50.687.
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