Glucuronosyl-disulfoglucosamine glucuronidase
In enzymology, a glucuronosyl-disulfoglucosamine glucuronidase (EC 3.2.1.56) is an enzyme that catalyzes the following chemical reaction:
- 3-D-glucuronosyl-N2,6-disulfo-beta-D-glucosamine + H2O D-glucuronate + N2,6-disulfo-D-glucosamine
| glucuronosyl-disulfoglucosamine glucuronidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.56 | ||||||||
| CAS number | 37288-42-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3-D-glucuronosyl-N2,6-disulfo-beta-D-glucosamine and H2O, whereas its two products are D-glucuronate and N2,6-disulfo-D-glucosamine.
This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is 3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase. Other names in common use include glycuronidase, and 3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase.
References
- Dietrich CP (May 1969). "Enzymic degradation of heparin. A glucosaminidase and a glycuronidase from Flavobacterium heparinum". Biochemistry. 8 (5): 2089–94. doi:10.1021/bi00833a046. PMID 5785227.
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