GDF7

Growth differentiation factor 7 (GDF7) is a protein that in humans is encoded by the GDF7 gene.[5]

GDF7
Identifiers
Aliases	GDF7, BMP12, growth differentiation factor 7
External IDs	OMIM: 604651 MGI: 95690 HomoloGene: 32177 GeneCards: GDF7
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.1 Start 20,667,144 bp[1] End 20,679,243 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 8,297,918 bp[2] End 8,301,954 bp[2]
Gene ontology Molecular function • cytokine activity • protein homodimerization activity • GO:0001948 protein binding • transforming growth factor beta receptor binding • growth factor activity Cellular component • extracellular region • extracellular Biological process • regulation of apoptotic process • pathway-restricted SMAD protein phosphorylation • cell fate commitment • epithelial cell differentiation • regulation of MAPK cascade • SMAD protein signal transduction • spinal cord association neuron differentiation • cell development • positive regulation of tendon cell differentiation • positive regulation of pathway-restricted SMAD protein phosphorylation • roof plate formation • BMP signaling pathway • axon guidance • reproductive structure development • positive regulation of transcription, DNA-templated • forebrain morphogenesis • gland morphogenesis • positive regulation of gene expression • positive regulation of neuron differentiation • neural tube development • branching morphogenesis of an epithelial tube • midbrain development • activin receptor signaling pathway • morphogenesis of an epithelial fold • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151449	238057
Ensembl	ENSG00000143869	ENSMUSG00000037660
UniProt	Q7Z4P5	P43029
RefSeq (mRNA)	NM_182828	NM_013527 NM_001312876
RefSeq (protein)	NP_878248	NP_001299805 NP_038555
Location (UCSC)	Chr 2: 20.67 – 20.68 Mb	Chr 12: 8.3 – 8.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

GDF7 belongs to the transforming growth factor beta superfamily that is specifically found in a signaling center known as the roof plate that is located in the developing nervous system of embryos. The roof plate is required for the generation of several classes of spinal cord dorsal interneurons; GDF7 specifically induces the formation of sensory neurons in the dorsal spinal cord from neural crest cells by generating signals within the roof plate.[5][6]

GDF7 is also known as bone morphogenic protein 12 (BMP-12).[7]

References

1. GRCh38: Ensembl release 89: ENSG00000143869 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037660 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee KJ, Mendelsohn M, Jessell TM (November 1998). "Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord". Genes Dev. 12 (21): 3394–407. doi:10.1101/gad.12.21.3394. PMC 317230. PMID 9808626.
6. Lo L, Dormand E, Anderson D (2005). "Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7". Proc Natl Acad Sci USA. 102 (20): 7192–7. doi:10.1073/pnas.0502581102. PMC 1091754. PMID 15883363.
7. Peng C, Lei C, Guofei C, Tian Y, Wei L, Jianwei Z, Chen W, Wentao Z, Changqing J (2019). "The application of BMP-12-overexpressing mesenchymal stem cells loaded 3D-printed PLGA scaffolds in rabbit rotator cuff repair". International Journal of Biological Macromolecules. 138: 79–88. doi:10.1016/j.ijbiomac.2019.07.041. PMID 31295489.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Davidson AJ, Postlethwait JH, Yan YL, et al. (1999). "Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily". Genome Res. 9 (2): 121–9. doi:10.1101/gr.9.2.121 (inactive 2021-01-14). PMID 10022976.CS1 maint: DOI inactive as of January 2021 (link)
• Butler SJ, Dodd J (2003). "A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons". Neuron. 38 (3): 389–401. doi:10.1016/S0896-6273(03)00254-X. PMID 12741987. S2CID 6434429.
• Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014. S2CID 23693180.