Bone morphogenetic protein 8A

Bone morphogenetic protein 8A (BMP8A) is a protein that in humans is encoded by the BMP8A gene.[5]

BMP8A
Identifiers
Aliases	BMP8A, entrez:353500, bone morphogenetic protein 8a, OP-2
External IDs	MGI: 104515 HomoloGene: 135983 GeneCards: BMP8A
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 39,491,636 bp[1] End 39,529,869 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.42 cM Start 123,312,645 bp[2] End 123,343,252 bp[2]
Gene ontology Molecular function • transforming growth factor beta receptor binding • cytokine activity • BMP receptor binding • growth factor activity Cellular component • extracellular region • extracellular Biological process • regulation of apoptotic process • multicellular organism development • positive regulation of pathway-restricted SMAD protein phosphorylation • cartilage development • negative regulation of insulin secretion • cell differentiation • regulation of MAPK cascade • SMAD protein signal transduction • cell development • BMP signaling pathway • ossification • diet induced thermogenesis • regulation of receptor activity • energy homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353500	12163
Ensembl	ENSG00000183682	ENSMUSG00000032726
UniProt	Q7Z5Y6	P34821
RefSeq (mRNA)	NM_181809	NM_001256019 NM_007558
RefSeq (protein)	NP_861525	NP_001242948 NP_031584
Location (UCSC)	Chr 1: 39.49 – 39.53 Mb	Chr 4: 123.31 – 123.34 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

BMP8A is a polypeptide member of the TGFβ superfamily of proteins. It, like other bone morphogenetic proteins (BMPs), is involved in the development of bone and cartilage. BMP8A may be involved in epithelial osteogenesis. It also plays a role in bone homeostasis. It is a disulfide-linked homodimer.

References

1. GRCh38: Ensembl release 89: ENSG00000183682 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032726 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: bone morphogenetic protein 8a".

External links

• Human BMP8A genome location and BMP8A gene details page in the UCSC Genome Browser.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.