Dermatitis

Dermatitis (also known as eczema) is inflammation of the skin, typically characterized by itchiness, redness and a rash.[1] In cases of short duration, there may be small blisters, while in long-term cases the skin may become thickened.[1] The area of skin involved can vary from small to covering the entire body.[1][2]

Dermatitis
Other namesEczema
A moderate case of dermatitis of the hands
SpecialtyDermatology
SymptomsItchiness, red skin, rash[1]
ComplicationsSkin infection[2]
Usual onsetChildhood[1][2]
CausesAtopic dermatitis, allergic contact dermatitis, irritant contact dermatitis, stasis dermatitis[1][2]
Diagnostic methodBased on symptom[1]
Differential diagnosisScabies, psoriasis, dermatitis herpetiformis, lichen simplex chronicus[3]
TreatmentMoisturizers, steroid creams, antihistamines[2][4]
Frequency245 million in 2015[5] (3.34% of world population)

Dermatitis includes atopic dermatitis, allergic contact dermatitis, irritant contact dermatitis and stasis dermatitis.[1][2] The exact cause of the condition is often unclear.[2] Cases may involve a combination of allergy and poor venous return.[1] The type of dermatitis is generally determined by the person's history and the location of the rash.[1] For example, irritant dermatitis often occurs on the hands of those who frequently get them wet.[1] Allergic contact dermatitis occurs upon exposure to an allergen, causing a hypersensitivity reaction in the skin.[1]

Treatment of atopic dermatitis is typically with moisturizers and steroid creams.[4] The steroid creams should generally be of mid- to high strength and used for less than two weeks at a time, as side effects can occur.[6] Antibiotics may be required if there are signs of skin infection.[2] Contact dermatitis is typically treated by avoiding the allergen or irritant.[7][8] Antihistamines may help with sleep and decrease nighttime scratching.[2]

Dermatitis was estimated to affect 245 million people globally in 2015,[5] or 3.34% of the world population. Atopic dermatitis is the most common type and generally starts in childhood.[1][2] In the United States, it affects about 10–30% of people.[2] Contact dermatitis is twice as common in females as males.[9] Allergic contact dermatitis affects about 7% of people at some point in their lives.[10] Irritant contact dermatitis is common, especially among people with certain occupations; exact rates are unclear.[11]

Signs and symptoms
Dermatitis of the hand

Dermatitis symptoms vary with all different forms of the condition. They range from skin rashes to bumpy rashes or including blisters.[12] Although every type of dermatitis has different symptoms, there are certain signs that are common for all of them, including redness of the skin, swelling, itching and skin lesions with sometimes oozing and scarring. Also, the area of the skin on which the symptoms appear tends to be different with every type of dermatitis, whether on the neck, wrist, forearm, thigh or ankle. Although the location may vary, the primary symptom of this condition is itchy skin. More rarely, it may appear on the genital area, such as the vulva or scrotum.[13][14] Symptoms of this type of dermatitis may be very intense and may come and go. Irritant contact dermatitis is usually more painful than itchy.

Although the symptoms of atopic dermatitis vary from person to person, the most common symptoms are dry, itchy, red skin. Typical affected skin areas include the folds of the arms, the back of the knees, wrists, face and hands. Perioral dermatitis refers to a red bumpy rash around the mouth.[15]

Dermatitis herpetiformis symptoms include itching, stinging and a burning sensation. Papules and vesicles are commonly present.[16] The small red bumps experienced in this type of dermatitis are usually about 1 cm in size, red in color and may be found symmetrically grouped or distributed on the upper or lower back, buttocks, elbows, knees, neck, shoulders, and scalp. Less frequently, the rash may appear inside the mouth or near the hairline.

The symptoms of seborrheic dermatitis, on the other hand, tend to appear gradually, from dry or greasy scaling of the scalp (dandruff) to scaling of facial areas, sometimes with itching, but without hair loss.[17] In newborns, the condition causes a thick and yellowish scalp rash, often accompanied by a diaper rash. In severe cases, symptoms may appear along the hairline, behind the ears, on the eyebrows, on the bridge of the nose, around the nose, on the chest, and on the upper back.[18]

  • Dermatitis
  • More severe dermatitis
  • A patch of dermatitis that has been scratched
  • Complex dermatitis

Cause

The cause of dermatitis is unknown but is presumed to be a combination of genetic and environmental factors.[2]

Environmental

The hygiene hypothesis postulates that the cause of asthma, eczema, and other allergic diseases is an unusually clean environment in childhood which leads to an insufficient human microbiota. It is supported by epidemiologic studies for asthma.[19] The hypothesis states that exposure to bacteria and other immune system modulators is important during development, and missing out on this exposure increases the risk for asthma and allergy.

While it has been suggested that eczema may sometimes be an allergic reaction to the excrement from house dust mites,[20] with up to 5% of people showing antibodies to the mites,[21] the overall role this plays awaits further corroboration.[22]

Genetic

A number of genes have been associated with eczema, one of which is filaggrin.[4] Genome-wide studies found three new genetic variants associated with eczema: OVOL1, ACTL9 and IL4-KIF3A.[23]

Eczema occurs about three times more frequently in individuals with celiac disease and about two times more frequently in relatives of those with celiac disease, potentially indicating a genetic link between the conditions.[24][25]

Pathophysiology

Eczema can be characterized by spongiosis which allows inflammatory mediators to accumulate. Different dendritic cells sub types, such as Langerhans cells, inflammatory dendritic epidermal cells and plasmacytoid dendritic cells have a role to play.[26][27]

Diagnosis

Diagnosis of eczema is based mostly on the history and physical examination.[4] In uncertain cases, skin biopsy may be taken for a histopathologic diagnosis of dermatitis.[28] Those with eczema may be especially prone to misdiagnosis of food allergies.[29]

Patch tests are used in the diagnosis of allergic contact dermatitis.[30][31]

Classification

The term eczema refers to a set of clinical characteristics. Classification of the underlying diseases has been haphazard with numerous different classification systems, and many synonyms being used to describe the same condition.

A type of dermatitis may be described by location (e.g., hand eczema), by specific appearance (eczema craquele or discoid) or by possible cause (varicose eczema). Further adding to the confusion, many sources use the term eczema interchangeably for the most common type: atopic dermatitis.

The European Academy of Allergology and Clinical Immunology (EAACI) published a position paper in 2001, which simplifies the nomenclature of allergy-related diseases, including atopic and allergic contact eczemas.[32] Non-allergic eczemas are not affected by this proposal.

Histopathologic classification
Main article: Histopathologic diagnosis of dermatitis

By histopathology, superficial dermatitis (in the epidermis, papillary dermis, and superficial vascular plexus) can basically be classified into either of the following groups:[33]

  • Vesiculobullous lesions
  • Pustular dermatosis
  • Non vesicullobullous, non-pustular
  • With epidermal changes
  • Without epidermal changes. These characteristically have a superficial perivascular inflammatory infiltrate and can be classified by type of cell infiltrate:[33]
  • Lymphocytic (most common)
  • Lymphoeosinophilic
  • Lymphoplasmacytic
  • Mast cell
  • Lymphohistiocytic
  • Neutrophilic

Terminology

There are several types of dermatitis including atopic dermatitis, contact dermatitis, stasis dermatitis and seborrheic eczema.[2] Many use the term dermatitis and eczema synonymously.[1]

Others use the term eczema to specifically mean atopic dermatitis.[34][35][36] Atopic dermatitis is also known as atopic eczema.[4] In some languages, dermatitis and eczema mean the same thing, while in other languages dermatitis implies an acute condition and eczema a chronic one.[37]

Common types

Diagnosis of types may be indicated by codes defined according to International Statistical Classification of Diseases and Related Health Problems (ICD).

Atopic

Atopic dermatitis is an allergic disease believed to have a hereditary component and often runs in families whose members have asthma. Itchy rash is particularly noticeable on head and scalp, neck, inside of elbows, behind knees, and buttocks. It is very common in developed countries and rising. Irritant contact dermatitis is sometimes misdiagnosed as atopic dermatitis. Stress can cause atopic dermatitis to worsen.[38]

Contact

Contact dermatitis is of two types: allergic (resulting from a delayed reaction to an allergen, such as poison ivy, nickel, or Balsam of Peru),[39] and irritant (resulting from direct reaction to a detergent, such as sodium lauryl sulfate, for example).

Some substances act both as allergen and irritant (wet cement, for example). Other substances cause a problem after sunlight exposure, bringing on phototoxic dermatitis. About three quarters of cases of contact eczema are of the irritant type, which is the most common occupational skin disease. Contact eczema is curable, provided the offending substance can be avoided and its traces removed from one's environment. (ICD-10 L23; L24; L56.1; L56.0)

Seborrhoeic

Seborrhoeic dermatitis or seborrheic dermatitis ("cradle cap" in infants) is a condition sometimes classified as a form of eczema that is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk. In newborns, it causes a thick, yellow, crusty scalp rash called cradle cap, which seems related to lack of biotin and is often curable. (ICD-10 L21; L21.0)

Dyshidrosis

Dyshidrosis (dyshidrotic eczema, pompholyx, vesicular palmoplantar dermatitis) only occurs on palms, soles, and sides of fingers and toes. Tiny opaque bumps called vesicles, thickening, and cracks are accompanied by itching, which gets worse at night. A common type of hand eczema, it worsens in warm weather. (ICD-10 L30.1)

Discoid

Discoid eczema (nummular eczema, exudative eczema, microbial eczema) is characterized by round spots of oozing or dry rash, with clear boundaries, often on lower legs. It is usually worse in winter. Cause is unknown, and the condition tends to come and go. (ICD-10 L30.0)

Venous

Venous eczema (gravitational eczema, stasis dermatitis, varicose eczema) occurs in people with impaired circulation, varicose veins, and edema, and is particularly common in the ankle area of people over 50. There is redness, scaling, darkening of the skin, and itching. The disorder predisposes to leg ulcers. (ICD-10 I83.1)

Herpetiformis

Dermatitis herpetiformis (Duhring's disease) causes an intensely itchy and typically symmetrical rash on arms, thighs, knees, and back. It is directly related to celiac disease, can often be put into remission with an appropriate diet, and tends to get worse at night. (ICD-10 L13.0)

Neurodermatitis

Neurodermatitis (lichen simplex chronicus, localized scratch dermatitis) is an itchy area of thickened, pigmented eczema patch that results from habitual rubbing and scratching. Usually, there is only one spot. Often curable through behaviour modification and anti-inflammatory medication. Prurigo nodularis is a related disorder showing multiple lumps. (ICD-10 L28.0; L28.1)

Autoeczematization

Autoeczematization (id reaction, auto sensitization) is an eczematous reaction to an infection with parasites, fungi, bacteria, or viruses. It is completely curable with the clearance of the original infection that caused it. The appearance varies depending on the cause. It always occurs some distance away from the original infection. (ICD-10 L30.2)

Viral

There are eczemas overlaid by viral infections (eczema herpeticum or vaccinatum), and eczemas resulting from underlying disease (e.g., lymphoma). Eczemas originating from ingestion of medications, foods, and chemicals, have not yet been clearly systematized. Other rare eczematous disorders exist in addition to those listed here.

Prevention

Exclusive breastfeeding of infants during at least the first few months may decrease the risk.[40] There is no good evidence that a mother's diet during pregnancy or breastfeeding affects the risk,[40] nor is there evidence that delayed introduction of certain foods is useful.[40] There is tentative evidence that probiotics in infancy may reduce rates but it is insufficient to recommend its use.[41]

Certain military and healthcare personnel who might come into contact with the smallpox are still vaccinated against the virus.[42] Those who also have eczema should not receive the smallpox vaccination due to risk of developing eczema vaccinatum, a potentially severe and sometimes fatal complication.[43]

Management

There is no known cure for some types of dermatitis, with treatment aiming to control symptoms by reducing inflammation and relieving itching. Contact dermatitis is treated by avoiding what is causing it.

Lifestyle

Bathing once or more a day is recommended, usually for five to ten minutes in warm water.[4][44] Soaps should be avoided, as they tend to strip the skin of natural oils and lead to excessive dryness.[45] The American Academy of Dermatology suggests using a controlled amount of bleach diluted in a bath to help with atopic dermatitis.[46]

There has not been adequate evaluation of changing the diet to reduce eczema.[47][48] There is some evidence that infants with an established egg allergy may have a reduction in symptoms if eggs are eliminated from their diets.[47] Benefits have not been shown for other elimination diets, though the studies are small and poorly executed.[47][48] Establishing that there is a food allergy before dietary change could avoid unnecessary lifestyle changes.[47]

People can wear clothing designed to manage the itching, scratching and peeling.[49]

House dust mite reduction and avoidance measures have been studied in low quality trials and have not shown evidence of improving eczema.[50]

Moisturizers

Low-quality evidence indicates that moisturizing agents (emollients) may reduce eczema severity and lead to fewer flares.[51] In children, oil–based formulations appear to be better, and water–based formulations are not recommended.[4] It is unclear if moisturizers that contain ceramides are more or less effective than others.[52] Products that contain dyes, perfumes, or peanuts should not be used.[4] Occlusive dressings at night may be useful.[4]

Some moisturizers or barrier creams may reduce irritation in occupational irritant hand dermatitis,[53] a skin disease that can affect people in jobs that regularly come into contact with water, detergents, chemicals or other irritants.[53] Some emollients may reduce the number of flares in people with dermatitis.[54]

Corticosteroids

If symptoms are well controlled with moisturizers, steroids may only be required when flares occur.[4] Corticosteroids are effective in controlling and suppressing symptoms in most cases.[55] Once daily use is generally enough.[4] For mild-moderate eczema a weak steroid may be used (e.g., hydrocortisone), while in more severe cases a higher-potency steroid (e.g., clobetasol propionate) may be used. In severe cases, oral or injectable corticosteroids may be used. While these usually bring about rapid improvements, they have greater side effects.

Long term use of topical steroids may result in skin atrophy, stria, telangiectasia.[4] Their use on delicate skin (face or groin) is therefore typically with caution.[4] They are, however, generally well tolerated.[56] Red burning skin, where the skin turns red upon stopping steroid use, has been reported among adults who use topical steroids at least daily for more than a year.[57]

Antihistamines

There is little evidence supporting the use of antihistamine medications for the relief of dermatitis.[4][58] Sedative antihistamines, such as diphenhydramine, may be useful in those who are unable to sleep due to eczema.[4] Second generation antihistamines have minimal evidence of benefit.[59] Of the second generation antihistamines studied, fexofenadine is the only one to show evidence of improvement in itching with minimal side effects.[59]

Immunosuppressants
Tacrolimus 0.1%

Topical immunosuppressants like pimecrolimus and tacrolimus may be better in the short term and appear equal to steroids after a year of use.[60] Their use is reasonable in those who do not respond to or are not tolerant of steroids.[61][62] Treatments are typically recommended for short or fixed periods of time rather than indefinitely.[4][63] Tacrolimus 0.1% has generally proved more effective than pimecrolimus, and equal in effect to mid-potency topical steroids.[64] There is no link to increased risk of cancer from topical use of 1% pimecrolimus cream.[63]

When eczema is severe and does not respond to other forms of treatment, systemic immunosuppressants are sometimes used. Immunosuppressants can cause significant side effects and some require regular blood tests. The most commonly used are ciclosporin, azathioprine, and methotrexate.

Dupilumab is a new medication that improves eczema lesions, especially moderate to severe eczema.[65] Dupilumab, a monoclonal antibody, suppresses inflammation by targeting the interleukin-4 receptor.

Light therapy

Light therapy using ultraviolet light has tentative support but the quality of the evidence is not very good.[66] A number of different types of light may be used including UVA and UVB;[67] in some forms of treatment, light sensitive chemicals such as psoralen are also used. Overexposure to ultraviolet light carries its own risks, particularly that of skin cancer.[68]

Alternative medicine

Limited evidence suggests that acupuncture may reduce itching in those affected by atopic dermatitis.[69] There is currently no scientific evidence for the claim that sulfur treatment relieves eczema.[70] It is unclear whether Chinese herbs help or harm.[71] Dietary supplements are commonly used by people with eczema.[72] Neither evening primrose oil nor borage seed oil taken orally have been shown to be effective.[73] Both are associated with gastrointestinal upset.[73] Probiotics are likely to make little to no difference in symptoms.[74] There is insufficient evidence to support the use of zinc, selenium, vitamin D, vitamin E, pyridoxine (vitamin B6), sea buckthorn oil, hempseed oil, sunflower oil, or fish oil as dietary supplements.[72]

Chiropractic spinal manipulation lacks evidence to support its use for dermatitis.[75] There is little evidence supporting the use of psychological treatments.[76] While dilute bleach baths have been used for infected dermatitis there is little evidence for this practice.[77]

Prognosis

Most cases are well managed with topical treatments and ultraviolet light.[4] About 2% of cases are not.[4] In more than 60% of young children, the condition subsides by adolescence.[4]

Epidemiology

Globally dermatitis affected approximately 230 million people as of 2010 (3.5% of the population).[78] Dermatitis is most commonly seen in infancy, with female predominance of eczema presentations occurring during the reproductive period of 15–49 years.[79] In the UK about 20% of children have the condition, while in the United States about 10% are affected.[4]

Although little data on the rates of eczema over time exists prior to the 1940s, the rate of eczema has been found to have increased substantially in the latter half of the 20th century, with eczema in school-aged children being found to increase between the late 1940s and 2000.[80] In the developed world there has been rise in the rate of eczema over time. The incidence and lifetime prevalence of eczema in England has been seen to increase in recent times.[4][81]

Dermatitis affected about 10% of U.S. workers in 2010, representing over 15 million workers with dermatitis. Prevalence rates were higher among females than among males, and among those with some college education or a college degree compared to those with a high school diploma or less. Workers employed in healthcare and social assistance industries and life, physical, and social science occupations had the highest rates of reported dermatitis. About 6% of dermatitis cases among U.S. workers were attributed to work by a healthcare professional, indicating that the prevalence rate of work-related dermatitis among workers was at least 0.6%.[82]

History
from Ancient Greek ἔκζεμα ékzema,[83]
from ἐκζέ-ειν ekzé-ein,
from ἐκ ek "out" + ζέ-ειν zé-ein "to boil"

(OED)

The term "atopic dermatitis" was coined in 1933 by Wise and Sulzberger.[84] Sulfur as a topical treatment for eczema was fashionable in the Victorian and Edwardian eras.[70]

The word dermatitis is from the Greek δέρμα derma "skin" and -ῖτις -itis "inflammation" and eczema is from Greek: ἔκζεμα ekzema "eruption".[85]

Society and culture

Some cosmetics are marketed as hypoallergenic to imply that their use is less likely to lead to an allergic reaction than other products.[86] However, the term "hypoallergenic" is not regulated,[87] and no research has been done showing that products labeled "hypoallergenic" are less problematic than any others. In 1977, courts overruled the U.S. Food and Drug Administration's regulation of the use of the term hypoallergenic.[86] In 2019, the European Union on released a document about claims made concerning cosmetics,[88] but this was issued as "guidance" not a regulation.[89]

Research

Monoclonal antibodies are under preliminary research to determine their potential as treatments for atopic dermatitis, with only dupilumab showing evidence of efficacy, as of 2018.[90][91]

See also

References
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