Complement component 7

Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.

C7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WCY
Identifiers
Aliases	C7, complement component 7, complement C7
External IDs	OMIM: 217070 MGI: 88235 HomoloGene: 489 GeneCards: C7
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.1 Start 40,909,497 bp[1] End 40,984,643 bp[1]
Gene ontology Molecular function • growth factor activity Cellular component • extracellular region • extracellular exosome • membrane attack complex Biological process • complement activation • cytolysis • regulation of complement activation • alternative complement pathway • immune response • classical complement pathway • immune system process • innate immune system • cellular sodium ion homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	730	109828
Ensembl	ENSG00000112936	ENSMUSG00000079105
UniProt	P10643	D3YXF5
RefSeq (mRNA)	NM_000587	NM_001243837
RefSeq (protein)	NP_000578	NP_001230766
Location (UCSC)	Chr 5: 40.91 – 40.98 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.

See also

• Terminal complement pathway deficiency

External links

• Complement+C7 at the US National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: P10643 (Human Complement component C7) at the PDBe-KB.

References

1. GRCh38: Ensembl release 89: ENSG00000112936 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.