Cefalotin
Cefalotin (INN) /ˌsɛfəˈloʊtɪn/ or cephalothin (USAN) /ˌsɛfəˈloʊθɪn/ is a first-generation cephalosporin antibiotic.[1] It was the first cephalosporin marketed (1964) and continues to be widely used.[2] It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.[3]
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AHFS/Drugs.com | International Drug Names |
MedlinePlus | a682860 |
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Routes of administration | Intravenous |
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Bioavailability | n/a |
Protein binding | 65 to 80% |
Metabolism | Hepatic |
Elimination half-life | 30 minutes to 1 hour |
Excretion | Renal |
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ECHA InfoCard | 100.005.288 |
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Formula | C16H16N2O6S2 |
Molar mass | 396.43 g·mol−1 |
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Melting point | 160 to 160.5 °C (320.0 to 320.9 °F) |
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References
- Hameed TK, Robinson JL (July 2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian Journal of Infectious Diseases. 13 (4): 253–8. doi:10.1155/2002/712594. PMC 2094874. PMID 18159398.
- Greenwood D (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. pp. 128–. ISBN 978-0-19-953484-5.
- International Drug Names: Cefalotin
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