Anti-actin antibodies

Anti-actin antibodies (AAA)[1] are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.

schematic representation of antibody.

In coeliac disease anti-actin antibodies correlated with the level of intestinal damage.[2][3]

In autoimmune hepatitis anti-actin antibodies correlate with patterns of immune recognition,[4] the pattern of recognition was specific to a small percentage of auto-immune hepatitis type 1 or cryptogenic hepatitis patients.[5]

In gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.[6]

It has also been found as a paraneoplastic syndrome with myelodysplastic syndrome.[7]

References
  1. Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 978-0-397-54589-6.
  2. Pedreira S, Sugai E, Moreno ML, et al. (2005). "Significance of smooth muscle/anti-actin autoantibodies in celiac disease". Acta Gastroenterol. Latinoam. 35 (2): 83–93. PMID 16127984.
  3. Carroccio A, Brusca I, Iacono G, et al. (2007). "IgA anti-actin antibodies ELISA in coeliac disease: A multicentre study" (PDF). Digestive and Liver Disease. 39 (9): 818–23. doi:10.1016/j.dld.2007.06.004. hdl:10447/34417. PMID 17652043.
  4. Muratori P, Muratori L, Agostinelli D, et al. (2002). "Smooth muscle antibodies and type 1 autoimmune hepatitis". Autoimmunity. 35 (8): 497–500. doi:10.1080/0891693021000054066. PMID 12765475.
  5. Ballot E, Homberg JC, Johanet C (2000). "Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis". J. Hepatol. 33 (2): 208–15. doi:10.1016/S0168-8278(00)80361-X. PMID 10952238.
  6. Konstandoulakis MM, Syrigos KN, Leandros M, Charalabopoulos A, Manouras A, Golematis BC (1998). "Autoantibodies in the serum of patients with gastric cancer: their prognostic importance". Hybridoma. 17 (5): 431–5. doi:10.1089/hyb.1998.17.431. PMID 9873988.
  7. Enright, Helen (Oct 1995). "Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: response to immunosuppressive therapy". British Journal of Haematology. 91 (2): 403–8. doi:10.1111/j.1365-2141.1995.tb05310.x. PMID 8547082.
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