Yatapoxvirus

Yatapoxvirus is a genus of viruses, in the family Poxviridae, in the subfamily Chordopoxvirinae. Monkeys and baboons serve as natural hosts. There are currently only two species in this genus including the type species Yaba monkey tumor virus. Diseases associated with this genus include: histiocytomas, tumor-like mass of mononuclear cells.[1][2]

Yatapoxvirus
Virus classification
(unranked): Virus
Realm: Varidnaviria
Kingdom: Bamfordvirae
Phylum: Nucleocytoviricota
Class: Pokkesviricetes
Order: Chitovirales
Family: Poxviridae
Subfamily: Chordopoxvirinae
Genus: Yatapoxvirus
Type species
Yaba monkey tumor virus

Taxonomy

Group: dsDNA

[2]

Structure

Viruses in Yatapoxvirus are enveloped, with brick-shaped geometries. The diameter is around 200 nm. Genomes are linear, around 145kb in length.[1]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
YatapoxvirusBrick-shapedEnvelopedLinearMonopartite

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. Fusion with the plasma membrane to release the core into the host cytoplasm. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV). IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV)host receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. DNA-templated transcription is the method of transcription. The virus exits the host cell by existing in occlusion bodies after cell death and remaining infectious until finding another host. Monkeys and baboons serve as the natural host. Transmission routes are mechanical and contact.[1]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
YatapoxvirusMonkeys; baboonsNoneGlycosaminoglycansLysis; buddingCytoplasmCytoplasmContact; insects

References
  1. "Viral Zone". ExPASy. Retrieved 15 June 2015.
  2. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
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