Xinnian Dong

Xinnian Dong (Chinese: 董欣年; pinyin: Dǒng Xīnnián; born 1959) is a Chinese-American biologist who is the current Arts and Sciences Professor of Biology in the Trinity College of Arts and Sciences, Duke University. She is a member of the US National Academy of Sciences.[1][2]

The native form of this personal name is Dong Xinnian. This article uses Western name order when mentioning individuals.
Xinnian Dong
董欣年
Born1959 (age 61–62)
Wuhan, Hubei, China
NationalityUnited States
Alma materWuhan University
Northwestern University
Harvard University
Spouse(s)Xiao-Fan Wang
Scientific career
FieldsMolecular biology
Plant physiology
InstitutionsDuke University

Biography

Dong was born in Wuhan, Hubei, China in 1959, to Dong Fureng (Chinese: 董辅礽), a Chinese-American economist, and Liu Ainian (Chinese: 刘蔼年), a Chinese-American ophthalmologist.[3] After resuming the college entrance examination, Dong was accepted to Wuhan University, where she graduated in 1982. After college, she attended the China-United States Biochemistry Examination and Application (CUSBEA) and was sent abroad to study at the expense of the Chinese government, along with her husband, Xiao-Fan Wang. In 1983, she pursued advanced studies in the United States, earning her doctorate from Northwestern University in 1988. Dong did post-doctoral research at Harvard University from 1988 to 1991. Dong joined the faculty of Duke University in 1992 and established the Dong Lab.

Since 1992, Dr. Dong and the Dong Lab has studied plant-microbe interactions with an emphasis on systemic acquired resistance (SAR)[4] The Lab's early work involved the identification of key components in SAR, including NPR1.[5][6][7][8] More recently, the Lab made discoveries which provided new insights into the relationship between pathogen-induced cellular redox changes and induced immune responses in plants[9] and the role of ER-resident genes in the modification and secretion of antimicrobial proteins.[10] Most recently, the Lab has conducted genomic studies, leading to the discovery of new components in R gene-mediated resistance against downy mildew (Hyaloperonospora parasitica).[11] They also currently investigate links between chromatin stability and plant defense.[12]

Personal life

She became a naturalized US citizen in 1998. Dong was married to Xiao-Fan Wang, a Chinese American oncologist.[13][14]

Awards and honors

References
  1. "XINNIAN DONG". asm.org. 2018. Retrieved 12 October 2018.
  2. "Profile of Xinnian Dong". pnas.org. 2018. Retrieved 12 October 2018.
  3. 董欣年：爸爸您好好休息吧（图）. Sohu (in Chinese). 2004-08-12.
  4. http://www.contextureintl.com, Designed by Contexture International |. "Dong Lab | Plant Immunity and Microbe Interactions". Retrieved 2020-07-12.
  5. Tada, Y.; Spoel, S. H.; Pajerowska-Mukhtar, K.; Mou, Z.; Song, J.; Wang, C.; Zuo, J.; Dong, X. (2008-08-15). "Plant Immunity Requires Conformational Charges of NPR1 via S-Nitrosylation and Thioredoxins". Science. 321 (5891): 952–956. doi:10.1126/science.1156970. ISSN 0036-8075. PMC 3833675. PMID 18635760.
  6. Spoel, Steven H.; Mou, Zhonglin; Tada, Yasuomi; Spivey, Natalie W.; Genschik, Pascal; Dong, Xinnian (May 2009). "Proteasome-Mediated Turnover of the Transcription Coactivator NPR1 Plays Dual Roles in Regulating Plant Immunity". Cell. 137 (5): 860–872. doi:10.1016/j.cell.2009.03.038. PMC 2704463.
  7. Saleh, Abdelaty; Withers, John; Mohan, Rajinikanth; Marqués, Jorge; Gu, Yangnan; Yan, Shunping; Zavaliev, Raul; Nomoto, Mika; Tada, Yasuomi; Dong, Xinnian (August 2015). "Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses". Cell Host & Microbe. 18 (2): 169–182. doi:10.1016/j.chom.2015.07.005. PMC 4537515. PMID 26269953.
  8. Withers, John; Dong, Xinnian (2016-08-11). Zipfel, Cyril (ed.). "Posttranslational Modifications of NPR1: A Single Protein Playing Multiple Roles in Plant Immunity and Physiology". PLOS Pathogens. 12 (8): e1005707. doi:10.1371/journal.ppat.1005707. ISSN 1553-7374. PMC 4981451. PMID 27513560.
  9. Tada, Y.; Spoel, S. H.; Pajerowska-Mukhtar, K.; Mou, Z.; Song, J.; Wang, C.; Zuo, J.; Dong, X. (2008-08-15). "Plant Immunity Requires Conformational Charges of NPR1 via S-Nitrosylation and Thioredoxins". Science. 321 (5891): 952–956. doi:10.1126/science.1156970. ISSN 0036-8075. PMC 3833675. PMID 18635760.
  10. Saleh, Abdelaty; Withers, John; Mohan, Rajinikanth; Marqués, Jorge; Gu, Yangnan; Yan, Shunping; Zavaliev, Raul; Nomoto, Mika; Tada, Yasuomi; Dong, Xinnian (August 2015). "Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses". Cell Host & Microbe. 18 (2): 169–182. doi:10.1016/j.chom.2015.07.005. PMC 4537515. PMID 26269953.
  11. Clarke, Joseph D.; Liu, Yidong; Klessig, Daniel F.; Dong, Xinnian (1998-04-01). "Uncoupling PR Gene Expression from NPR1 and Bacterial Resistance: Characterization of the Dominant Arabidopsis cpr6-1 Mutant". The Plant Cell. 10 (4): 557–569. doi:10.1105/tpc.10.4.557. ISSN 1040-4651. PMC 144011. PMID 9548982.
  12. Withers, John; Dong, Xinnian (2016-08-11). Zipfel, Cyril (ed.). "Posttranslational Modifications of NPR1: A Single Protein Playing Multiple Roles in Plant Immunity and Physiology". PLOS Pathogens. 12 (8): e1005707. doi:10.1371/journal.ppat.1005707. ISSN 1553-7374. PMC 4981451. PMID 27513560.
  13. 王小凡和董欣年：中美院士伉俪竟是武大同学. Sohu (in Chinese). 2017-12-01.
  14. 杰出校友王小凡、董欣年教授重回母校. whu.edu.cn (in Chinese). 2018-06-13.
  15. 董欣年的珞珈情缘. Chinadaily (in Chinese). 2012-07-02.
  16. "The World's Most Influential Scientific Minds - 2015" (PDF). 2015.
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