Urtoxazumab
Urtoxazumab is a humanized monoclonal antibody against diarrhoea caused by Escherichia coli, serotype O121. The drug is designed to bind to a toxin of this bacterium, so that it can be more easily broken down and eliminated from the body.[1][2]
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | E. coli Shiga-like toxin II B subunit |
| Clinical data | |
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C6414H9934N1718O2010S40 |
| Molar mass | 144556.44 g·mol−1 |
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References
- "International Nonproprietary Names for Pharmaceutical Substances (INN)" (PDF). World Health Organization.
- López EL, Contrini MM, Glatstein E, González Ayala S, Santoro R, Allende D, et al. (January 2010). "Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli". Antimicrobial Agents and Chemotherapy. 54 (1): 239–43. doi:10.1128/AAC.00343-09. PMC 2798559. PMID 19822704.
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