Thiosulfate—dithiol sulfurtransferase
In enzymology, a thiosulfate-dithiol sulfurtransferase (EC 2.8.1.5) is an enzyme that catalyzes the chemical reaction
- thiosulfate + dithioerythritol sulfite + 4,5-cis-dihydroxy-1,2-dithiacyclohexane (i.e. oxidized dithioerythritol) + sulfide
| thiosulfate-dithiol sulfurtransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.1.5 | ||||||||
| CAS number | 9059-49-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are thiosulfate and dithioerythritol, whereas its 3 products are sulfite, 4,5-cis-dihydroxy-1,2-dithiacyclohexane, and sulfide.
This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is thiosulfate:dithioerythritol sulfurtransferase. Other names in common use include thiosulfate reductase, and TSR. This enzyme participates in sulfur metabolism.
References
- Schmidt A, Erdle I, Gamon B (1984). "Isolation and characterization of thiosulfate reductases from the green alga Chlorella fusca". Planta. 162: 243–249. doi:10.1007/BF00397446. PMID 24253096.
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