TRIM33

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.[5][6]

TRIM33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U5M, 3U5N, 3U5O, 3U5P
Identifiers
Aliases	TRIM33, ECTO, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA, tripartite motif containing 33
External IDs	OMIM: 605769 MGI: 2137357 HomoloGene: 9296 GeneCards: TRIM33
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 114,392,790 bp[1] End 114,511,203 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 103,279,293 bp[2] End 103,358,775 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • R-SMAD binding • co-SMAD binding • zinc ion binding • metal ion binding • ubiquitin-protein transferase activity • GO:0001948 protein binding • transferase activity Cellular component • intracellular • cell nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of BMP signaling pathway • protein ubiquitination • negative regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51592	94093
Ensembl	ENSG00000197323	ENSMUSG00000033014
UniProt	Q9UPN9	Q99PP7
RefSeq (mRNA)	NM_015906 NM_033020	NM_001079830 NM_053170
RefSeq (protein)	NP_056990 NP_148980	NP_001073299 NP_444400
Location (UCSC)	Chr 1: 114.39 – 114.51 Mb	Chr 3: 103.28 – 103.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.[5]

Structure

The protein is a member of the tripartite motif family.[7] This motif includes three zinc-binding domains:

• RING
• B-box type 1 zinc finger
• B-box type 2 zinc finger

and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[5]

Interactions

TRIM33 has been shown to interact with TRIM24.[8]

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.[9] TRIM33 regulates also the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells. [10] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.[11]

References

1. GRCh38: Ensembl release 89: ENSG00000197323 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033014 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TRIM33 tripartite motif-containing 33".
6. Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
7. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
8. Peng H, Feldman I, Rauscher FJ (July 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
9. Aucagne R, Droin N, Paggetti J, Lagrange B, Largeot A, Hammann A, Bataille A, Martin L, Yan KP, Fenaux P, Losson R, Solary E, Bastie JN, Delva L (June 2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". The Journal of Clinical Investigation. 121 (6): 2361–70. doi:10.1172/JCI45213. PMC 3104753. PMID 21537084.
10. Quéré R, Saint-Paul L, Carmignac V, Martin RZ, Chrétien ML, Largeot A, Hammann A, Pais de Barros JP, Bastie JN, Delva L (July 2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America. 111 (29): 10592–7. doi:10.1073/pnas.1405546111. PMC 4115559. PMID 25002492.
11. Wang E, Kawaoka S, Roe JS, Shi J, Hohmann AF, Xu Y, Bhagwat AS, Suzuki Y, Kinney JB, Vakoc CR (April 2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife. 4: e06377. doi:10.7554/eLife.06377. PMC 4409649. PMID 25919951.

Further reading

• Venturini L, You J, Stadler M, Galien R, Lallemand V, Koken MH, Mattei MG, Ganser A, Chambon P, Losson R, de Thé H (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene. 18 (5): 1209–17. doi:10.1038/sj.onc.1202655. PMID 10022127.
• Klugbauer S, Rabes HM (July 1999). "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene. 18 (30): 4388–93. doi:10.1038/sj.onc.1202824. PMID 10439047. S2CID 2166439.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
• Peng H, Feldman I, Rauscher FJ (July 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology. 320 (3): 629–44. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914.
• Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Dupont S, Zacchigna L, Cordenonsi M, Soligo S, Adorno M, Rugge M, Piccolo S (April 2005). "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase". Cell. 121 (1): 87–99. doi:10.1016/j.cell.2005.01.033. PMID 15820681. S2CID 16628152.
• He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massagué J (June 2006). "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway". Cell. 125 (5): 929–41. doi:10.1016/j.cell.2006.03.045. PMID 16751102. S2CID 17708166.

External links

• TRIM33+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.